Crucible of Science: The Story of the Cori Laboratory

Hardcover | March 21, 2013

byJohn H. Exton

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Crucible of Science is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escapedeteriorating conditions in Europe. Carl soon received an offer from Washington University to become Pharmacology Chair, and the couple settled in St. Louis. Not only did both Coris go on to win the Nobel Prize, the laboratory they established at the University has since produced some of the mostoutstanding scientists the U.S. has ever seen. Six laboratory scientists also won Nobel Prizes; few, if any, laboratories can claim such an impressive record. The Coris themselves were instrumental in establishing the then new science of Biochemistry in the U.S. They applied chemical approaches toelucidating the transformations of compounds such as glucose in animal tissues and defined the enzyme catalysts that carried out those transformations. Both scientists were extremely rigorous in designing their experiments and interpreting the results, a habit that ensured their findings were abovequestion. This book examines the careers of both Coris and the other eminent scientists who trained in their laboratory. It notes the Coris' acceptance of women, Jews, and scientists from all over the world, unique during this time period. It analyzes those reasons why the laboratory was so successful inattracting the best trainees and producing premier scientists. Intended for scientists, science historians, and anyone interested in the history of science, Crucible of Science is a unique presentation of remarkable careers and personalities, examined within the context of the Coris'laboratory.

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Crucible of Science is the story of a unique laboratory at Washington University in St. Louis, and of Carl and Gerty Cori, the biochemists who established it. Carl and Gerty met and married at medical school in Prague in the 1920s. After graduation, they immigrated to the U.S. to escapedeteriorating conditions in Europe. Carl soon rece...

John H. Exton is Professor of Molecular Physiology and Biophysics at the Vanderbilt University School of Medicine, and Investigator at Howard Hughes Medical Institute.

other books by John H. Exton

Format:HardcoverDimensions:372 pages, 9.25 × 6.12 × 0.98 inPublished:March 21, 2013Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199861072

ISBN - 13:9780199861071

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Table of Contents

Introduction1. Carl and Gerty Cori2. Sidney Colowick - Their First Graduate Student3. Herman Kalckar - The Great Dane4. Severo Ochoa - Spanish Genius5. Move to Enzymology and Work of Arda Green6. Luis Leloir - One of Argentina's Greatest Scientists7. Earl Sutherland - Master of Intuition8. Cori's Move to the Department of Biolgoical Chemistry - Award of Nobel Prizes and Career of Tom Cori9. Sidney Velick - Modest Enzymologist10. Victor Najjar - Pediatrician and Immunochemist11. Edwin Krebs - Accidental Biochemist12. Mildred Cohn - Against All Odds13. Christian de Duve - Belgian with Savoir Faire14. Arthur Kornberg - A Giant of Biochemistry15. Hormone Effects on Muscle Carbohydrate Metabolism16. Charles Park - Aristocratic Physiologist17. Jane Harting Park - Enthusiast for Science18. Gerty cori's Work on Glycogen Structure and Glycogen Storage Diseases19. Joseph Larner - Focus on Glycogen Synthase20. Contributions of Barbara and David Brown21. William Daughaday - All About Growth22. Robert Crane - A Decade With Carl Cori23. Alberto Sols - Spanis Enzymologist24. Luis Glaser - The Complexity of Carbohydrates25. Ernst Helmreich - Jovial Bavarian26. Carl Frieden - Enzyme Kineticist27. David Kipnis - Diabetologist28. William Danforth - Academic Leader29. The Influence of the Coris on Washington University and Carl Cori's Research at Boston30. The Heritage of the Coris