Cryptosporidium: From Molecules to Disease

Other | December 1, 2003

byThompson, R.C.A., R.c.a. Thompson

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In the relatively short period since Cryptosporidium was recognised as a human pathogen, and that it could be transmitted in water as well as directly between animals and people, it has been the subject of intense investigations. Its status as an opportunistic pathogen, especially in AIDS patients, and the lack of effective anti-cryptosporidial drugs have served to emphasise the public health importance of this organism. This has to some extent overshadowed the fact that Cryptosporidium is also an important pathogen of domestic animals and wildlife.

In recent years, the application of molecular biology and culture techniques have had an enormous impact on our understanding of the aetiological agents of cryptosporidial infections and our ability to study the causative agents in the laboratory. As a consequence, a wealth of information and novel data has been produced during the last 3-4 years, particularly in the areas of taxonomy, biology, pathogenesis, epidemiology - particularly zoonotic and water borne transmission, and treatment.

It is thus very timely to bring together in this book the international research community involved to review the major advances in research and identify the important research priorities for the future, thus enabling as wide an audience as possible to benefit from and share in this comprehensive look at Cryptosporidium and cryptosporidiosis.

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In the relatively short period since Cryptosporidium was recognised as a human pathogen, and that it could be transmitted in water as well as directly between animals and people, it has been the subject of intense investigations. Its status as an opportunistic pathogen, especially in AIDS patients, and the lack of effective anti-crypto...

Format:OtherDimensions:468 pages, 1 × 1 × 1 inPublished:December 1, 2003Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080530109

ISBN - 13:9780080530109


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Table of Contents

Preface (A. Thompson). Introduction: Cryptosporidium: from molecules to disease (G. Meinke).Cryptosporidiosis - Aetiology, Infectivity and Pathogenesis.Cryptosporidium:they probably taste like chicken (S.J. Upton).Cryptosporidium:from molecules to disease (R. Fayer).Cryptosporidium parvum:infectivity, pathogenesis and the host-parasite relationship (C.L. Chappell, P.C. Okhuysenet al.). What is the clinical and zoonotic significance of cryptosporidiosis in domestic animals and wildlife (M.E. Olson, B.J. Ralstonet al.).Extended Abstracts.Control ofCryptosporidium parvuminfection and the role of IL-4 in two strains of inbred mice (C.A. Notley, S.A.C. Mcdonaldet al.). Human peripheral CD8+CD103+T-lymphocyte transmigration through invertedCryptosporidium parvumsporozoite infected HCT-8 cell monolayers (G. Gargala, A. Delaunayet al.).Cryptosporidium parvumvolunteer study: infectivity and immunity (C.L. Chappell, P.C. Okhuysenet al.). Transmission of human genotype 1Cryptosporidium parvuminto lambs (M. Giles, D.C. Warhurset al.). A longitudinal study ofCryptosporidiumprevalence and its impact on performance in feedlot cattle (B.J. Ralston, M.E. Olsonet al.). Identification and characterisation of the antigenic CPA135 protein (F. Tosini, A. Agnoliet al.). A permanent method for detecting
Cryptosporidium parvumlife cycle stages inin vitroculture (H.V. Smith, R.A. Nicholset al.).
Successful cultivation ofCryptosporidiumreveals previously undescribed Gregarino-like developmental stages (N. Hijjawi, B.P. Meloniet al.).Epidemiology and species differentiation.Cryptosporidiumas a public health challenge (R.M. Chalmers). The zoonotic potential ofCyptosporidium(R.C.A. Thompson). Molecular epidemiology of human cryptosporidiosis (L. Xiao, C. Bernet al.). Molecular characterisation and taxonomy ofCryptosporidium(U.M. Ryan).Extended Abstracts.Antigenic differences inCryptosporidium parvumoocysts: the "Iowa strain" enigma (A. Ronald, S. Birrellet al.). Antigenic analysis ofCryptosporidium parvumisolates of human and animal origin (A. Ronald, J.E. O'Grady, H.V. Smith). Typing ofCryptosporidium parvumoocysts using phage-display technology (C. Lima, H.V. Smithet al.). High resolution genotyping ofCryptosporidiumby mutation scanning (A. El-Osta, Y. Zhuet al.). Evaluation of oocyst DNA extraction methods using real-time PCR (P. Monis, A. Keeganet al.). Differentiation ofCryptosporidium parvumsubtypes by a novel microsatelite-telomere PCR with page (S.A. Blasdall, J.E. Ongerth, N. Ashbolt). Genotypic variation ofCryptosporidiumorganisms recovered from persons living in Kenya, Malawi, Vietnam and Brazil (W. Gatei, C.A. Hartet al.). Epidemiological surveys of cryptosporidiosis in Thai orphans (M. Mungthin, T. Naagloret al.).CryptosporidiumandCyclospora-associated diarrhea in Kathmandu, Nepal (K. Ono, K. Kimuraet al.). Ecology of zoonotic cryptosporidiosis in watersheds containing cattle farming operations (T.K. Graczyk, C.J. Shiffet al.). Identifying variation among human, animal and environmental isolates ofCryptosporidium(R.M. Chalmers).Cryptosporidiumin eastern grey kangaroosMacropus giganteus(M.L. Power, M.B. Sladeet al.).Viability and infectivity.Detection of infectiousCryptosporidium parvumoocysts in environmental water samples (G.D. Di Giovanni, R. Aboytes). Measuring inactivation ofCryptosporidium parvumbyin vitrocell culture (P.A. Rochelle, A.A Mofidiet al.).In vitrocultivation and development ofCryptosporidiumin cell culture (N. Hijjawi).Extended Abstracts.The use of cell culture and real-time PCR to assess disinfection ofCryptosporidium parvum(A. Keegan, S. Geloneseet al.). Inactivation ofCryptosporidium parvumoocysts by low pressure UV-light (P. Karanis, D. Schoenen, O. Hoyer). Detection of viable oocysts ofCryptosporidium parvumby nucleic acid sequence-based amplification (NASBA) (C.J. Lowery, J.E. Mooreet al.). Flow cytometric evaluation ofCryptosporidium parvumoocyst viability (A. Delaunaya, G. Gargalaaet al.).Cryptosporidiumand the environment.The public health significance ofCryptosporidiumin the environment (P.T. Monis, R.M. Chalmers). Assessing variables in disinfection parameters ofCryptosporidium parvumoocysts (M.M. Marshall). Detection ofCryptosporidiumoocysts in water matrices (F.W. Schaefer III). Microbiological health criteria forCryptosporidium(C. Ferguson, G. Medemaet al.). Case-control studies of sporadic Cryptosporidiosis in Melbourne and Adelaide (B.R. Robertson, C.K. Fairleyet al.). The DWI licensed inter-laboratoryCryptosporidiumproficiency scheme (CRYPTS) (H.V. Smith, B.M. Campbell, J. Peet).Extended Abstracts.Detection ofCryptosporidiumspp. via fluorescentin situhybridisation: novel approaches of background reduction and signal enhancement (M. Dorsch, D.A. Veal). The risk ofCryptosporidiumto Sydney's drinking water supply (P. Cox, P. Hawkinset al.). Outbreak of waterborne Cryptosporidiosis at North Battleford, SK, Canada (P. Wallis, N. Bounsombathet al.). Event sampling forCryptosporidiumandGiardiain
South Australian water sources (S. Hayes, P. Dobsonet al.). Drinking water regulations forCryptosporidumin England and Wales (D. Drury, A. Lloyd). WhyCryptosporidiumresearch for large water supplies: investigations in the Lake Mornos, the big water reservoir of Greater Athens, Greece (P. Karanis, C. Papadopoulouet al.). NATA accreditation of laboratories testing water for the presence of parasitic protozoa (T.G. Orlova). Use of ferric sulfate flocculation method for the recovery ofCryptosporidiumoocysts from drinking water (P. Karanis, A. Kimura). A sensitive, semi-quantitative direct PCR-RFLP assay for simultaneous detection of fiveCryptosporidiumspecies in treated drinking waters and mineral waters (R.A.B. Nichols, C.A. Patonet al.). The incidence ofCryptosporidiumandGiardiain private water supplies in the United Kingdom (J. Watkins, D. Drury). The problem withCryptosporidiumin swimming pools (G. Nichols, R. Chalmerset al.).Cryptosporidium parvumoocyst recovery using immunomagnetisable separation (C.A. Paton, D.E. Kelseyet al.). Significance of enhanced morphological detection ofCryptosporidiumsp. oocysts in water concentrates using DAPI and immunofluorescence microscopy (H.V. Smith, B.M. Campbellet al.). Surveillance of Cryptosporidiosis: progressive approaches (G. Nichols, J. McLauchlinet al.). Cryptosporidium and the environment - overview and summary (R.M. Chalmers, P. Monis).Cryptosporidium- chemotherapy.A review of chemotherapeutic approaches to the treatment ofCryptosporidium(A. Armson, J.A. Reynoldson, R.C.A. Thompson).Extended Abstracts.An examination of the activity of the dinitroanilines onCryptosporidium parvumusingin vitro,in vivoand target expression methods (A. Armson, R.C.A. Thompsonet al.). Nitazoxanide in the treatment of cryptosporidiosis (J.F. Rossignol, A. Youbet al.). The application of quantitative-PCR for high throughput screening of novel compounds againstCryptosporidium parvumin vitroand their subsequent IC50determination (L. Pallant, L. Macdonaldet al.). Development of a standard method to recover protozoan parasites from soft fruit and salad vegetables (C.A. Paton, N. Wilkinsonet al.). How safe is drinking water in primary schools? (U. Chukohtuad, V. Suphiphat).Synthesis.Facilitators: (P. O'Donoghue, S. Uptonet al.).