Crystals, X-rays and Proteins: Comprehensive Protein Crystallography

Paperback | March 25, 2015

byDennis Sherwood, Jon Cooper

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A complete account of the theory of the diffraction of X-rays by crystals, with particular reference to the processes of determining the structures of protein molecules. This book is aimed primarily at structural biologists and biochemists but will also be valuable to those entering the fieldwith a background in physical sciences or chemistry. It may be used at any post-school level, and develops from first principles all relevant mathematics, diffraction and wave theory, assuming no mathematical knowledge beyond integral calculus. The book covers a host of important topics in the area, including:* The practical aspects of sample preparation and X-ray data collection, using both laboratory and synchrotron sources * Data analysis at both theoretical and practical levels* The important role played by the Patterson function in structure analysis, by both molecular replacement and experimental phasing approaches * Methods for improving the resulting electron density map * The theoretical basis of methods used in refinement of protein crystal structures * In-depth explanation of the crucial task of defining the binding sites of ligands and drug molecules * The complementary roles of other diffraction methods: these reveal further detail of great functional importance in a crystal structure.

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A complete account of the theory of the diffraction of X-rays by crystals, with particular reference to the processes of determining the structures of protein molecules. This book is aimed primarily at structural biologists and biochemists but will also be valuable to those entering the fieldwith a background in physical sciences or ch...

Dennis Sherwood read Natural Sciences as a scholar at Clare College, Cambridge, and subsequently won a Mellon Fellowship to the Department of Molecular Biophysics and Biochemistry at Yale University (MPhil), and a Calbiochem Scholarship to the University of California at San Diego (PhD). After a brief period as an ICI Post-doctoral Fe...

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Format:PaperbackDimensions:640 pagesPublished:March 25, 2015Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198726325

ISBN - 13:9780198726326

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Table of Contents

Part I: Fundamentals1. The crystalline state and its study2. Vector analysis and complex algebra3. Crystal systematics4. Waves and electromagnetic radiation5. Fourier transforms and convolutions6. DiffractionPart II: Diffraction Theory7. Diffraction by one-dimensional obstacles8. Diffraction by a three-dimensional lattice9. The contents of the unit cellPart III: Structure Solution10. Experimental techniques: sample preparation11. Experimental techniques: data collection and analysis12. The phase problem and the Patterson function13. Molecular replacement14. Solving the phase problem experimentally15. Model-building and refinement16. Complementary diffraction methods

Editorial Reviews

"A welcome addition to any structural biology laboratory, [and] an invaluable reference, answering questions in an accurate and transparent manner" --Karen McLuskey, Chemistry World March 2011