Current Concepts in Drug Metabolism and Toxicology

Other | November 27, 2012

byGabrielle M. Hawksworth, Gabrielle M. Hawksworth

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This new volume ofAdvances in Pharmacologyexplores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.



  • Explores the current concepts in drug metabolism and toxicology
  • Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity
  • An essential resource for pharmacologists, immunologists and biochemists alike

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This new volume ofAdvances in Pharmacologyexplores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of cha...

Format:OtherDimensions:304 pages, 1 × 1 × 1 inPublished:November 27, 2012Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123983592

ISBN - 13:9780123983596

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Table of Contents

  1. Membrane Transporters in Drug Development
  2. The Keap1-Nrf2 Cell Defence Pathway - A Promising Therapeutic Target?
  3. Animal Models of Idiosyncratic Drug Reactions
  4. Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical Aspects
  5. Arylamine N-Acetyltransferases - from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention
  6. Human Pluripotent Stem Cells for Modelling Toxicity
  7. Disposition of Biologics