Cystogenesis by Jong Hoon ParkCystogenesis by Jong Hoon Park


byJong Hoon ParkEditorCurie Ahn

Hardcover | October 26, 2016

Pricing and Purchase Info

$215.41 online 
$248.50 list price save 13%
Earn 1,077 plum® points

Prices and offers may vary in store


In stock online

Ships free on orders over $25

Not available in stores


Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.

Title:CystogenesisFormat:HardcoverDimensions:126 pages, 23.5 × 15.5 × 0.03 inPublished:October 26, 2016Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:981102040X

ISBN - 13:9789811020407

Look for similar items by category:


Table of Contents

Part I ADPKD Overview.- Chapter 1 Recent Trends in ADPKD Research.- Chapter 2 Genetic Mechanisms of ADPKD.- Part II Cystogenesis Mechanisms.- Chapter 3 Cell Proliferation and Apoptosis in ADPKD.- Chapter 4 Inflammation and Fibrosis in ADPKD.- Chapter 5 Functional Study of the Primary Cilia in ADPKD.- Chapter 6 Epigenetic Regulation in Cystogenesis.- Part III Therapeutic Approaches and Diagnostic Markers for ADPKD.- Chapter 7 Validation of Effective Therapeutic Targets for ADPKD using Animal Models.- Chapter 8 Diagnostic Evaluation as a Biomarker in Patients with ADPKD.- Chapter 9 Clinical Trials and a View toward the Future of ADPKD.