Cytokine Knockouts by Giamila FantuzziCytokine Knockouts by Giamila Fantuzzi

Cytokine Knockouts

EditorGiamila Fantuzzi

Paperback | November 9, 2010

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Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.
Title:Cytokine KnockoutsFormat:PaperbackDimensions:492 pages, 10 × 7.01 × 0.68 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374156

ISBN - 13:9781617374159

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Table of Contents

Part I. Cytokine Knockouts in Models of Human DiseaseCytokine Knockouts in InflammationPietro GhezziThe Use of Cytokine Knockouts to Study Host Defense Against InfectionCharles A. DinarelloThe Use of Cytokine Knockouts in Animal Models of Autoimmune DiseaseAlfons Billiau, Hubertine Heremans, and Patrick MatthysThe Use of Cytokine Knockout Mice in Cancer ResearchRobert H. Wiltrout, Jon M. Wigginton, and William J. MurphyThe Use of Cytokine Knockout Mice in NeuroimmunologyGiamal N. Luheshi, Emmanuel Pinteaux, and Hervé BoutinPart II. Cytokine Knockout MiceThe Role of IL-1 in the Immune SystemSusumu Nakae, Reiko Horai, Yutaka Komiyama, Aya Nambu, Masahide Asano, Akio Nakane, and Yoichiro IwakuraIL-1 Receptor Antagonist-Deficient MiceMartin J. H. Nicklin and Joanna ShepherdA Unique Role for IL-2 in Self-ToleranceThomas Hünig and Anneliese SchimplMolecular Basis for Binding Multiple Cytokines by gc: Implications for X-SCID and Impaired gc-Dependent Cytokine Receptor FunctionFerenc Olosz and Thomas R. MalekG-CSF, GM-CSF, and IL-3 Knockout MiceThomas Enzler and Glenn DranoffIL-4 Knockout MicePascale Kropf and Ingrid MüllerRole of IL-5 in Immune and Pathological Responses in the MousePaul S. Foster and Simon P. Hogan. IL-6 Knockout Mice, Valeria Poli and Diego MaritanoIL-10 and IL-2 Knockout Mice: Effect on Intestinal InflammationKaren L. Madsen and Humberto JijonIL-12-Deficient MiceLuciano AdoriniIL-13 and Double IL-4/IL-13 Knockout MiceDuncan R. Hewett and Andrew N. J. McKenzieIL-15: Insights from Characterizing IL-15-Deficient MicePallavur V. Sivakumar, Sandra N. Brown, Ananda W. Goldrath, Anne Renee Van der Vuurst de Vries, Joanne L. Viney, and Mary K. KennedyIL-18 and IL-18 Receptor Knockout MiceHiroko Tsutsui, Tomohiro Yoshimoto, Haruki Okamura, Shizuo Akira, and Kenji NakanishiMice Knockouts for Chemokines and Chemokine ReceptorsJane M. Schuh, Steven L. Kunkel, and Cory M. HogaboamIFN-g and IFN-g Receptor Knockout Mice, Dyana DaltonMacrophage Migration Inhibitory Factor (MIF)-Deficient MiceGunter Fingerle-Rowson, Abhay R. Satoskar, Richard BucalaOsteopontin, a Surprisingly Flexible Cytokine: Functions Revealed from Osteopontin Knockout MiceSusan R. Rittling, Anthony W. O'Regan, and Jeffrey S. BermanRANKL, RANK, and OPGYoung-Yun Kong and Josef M. PenningerTargeting the TGF-b Pathway In Vivo: Defining Complex Roles for TGF-b Signaling in Immune Function, Wound Healing, and CarcinogenesisLawrence Wolfraim, Mizuko Mamura, Anita Roberts, and John J. LetterioPhysiologic Roles of Members of the TNF and TNF Receptor Families as Revealed by Knockout ModelsSergei A. Nedospasov, Sergei I. Grivennikov, and Dmitry V. KuprashIndex

Editorial Reviews

Foreword by Scott K. Durum Reviews of the first edition:...should be the most useful for everybody who wants to learn about those thrilling, novel leads into the biology of the immune system and the pathogenesis of human diseases. -from the Foreword by Klaus Rajewsky, Institute of Genetics, Cologne". . .a very nice compendium of research in a very important area . . . should be on the shelves of all life science and biomedical libraries."-5 Stars, Doody's Health Sciences Book Review Journal"...essential reading for...laboratory scientists, including immunologists, developmental and cell biologists, and experimental pathologists..." -Modern Pathology "...a very nice compendium of research in a very important area...should be on the shelves of all life science/biomedical libraries." -Doody's Health Sciences Book Review Journal"This remarkable book is a powerful source of information and ideas." -Annales de Biologie Clinique