Cytokines, Stress, And Depression

Hardcover | July 31, 1999

EditorRobert Dantzer, Emmanuelle E. Wollmann, Raz Yirmiya

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Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.

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Until a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a ...

Format:HardcoverDimensions:347 pages, 9.21 × 6.14 × 0.27 inPublished:July 31, 1999Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0306461358

ISBN - 13:9780306461354

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Table of Contents

List of Contributors. Preface; R. Dantzer, et al. Section I: Depression and Immunity. 1. Immune Correlates of Depression; M. Irwin. 2. Major Depression and Activation of the Inflammatory Response System; M. Maes. 3. Cytokine Production in Depressed Patients; A. Seidel, et al. 4. Indicators of Immune Activation in Depressed Patients; A. Sluzewska. Section II: Brain Effects of Cytokines. 5. Mood and Cognitive Disorders in Cancer Patients Receiving Cytokine Therapy; C.A. Meyers. 6. Mechanisms of the Behavioural Effects of Cytokines; R. Dantzer, et al. 7. Effects of Cytokines on Glucocorticoid Receptor Expression and Function: Glucocorticoid Resistance and Relevance to Depression; A.H. Miller, et al. 8. Effects of Cytokines on Cerebral Neurotransmission: Comparison with the Effects of Stress; A.J. Dunn, et al. 9. Inflammation and Brain Function under Basal Conditions and During Long-Term Elevation of Brain Corticotropin-Releasing Hormone Levels; A.C.E. Linthorst, J.M.H.M. Reul. Section III: Effects of Stress on Cytokine Production and Actions. 10. Dynamic Regulation of Proinflammatory Cytokines; L.R. Watkins, et al. 11. Cross-Sensitization between Immune and Non Immune Stressors: A Role in the Etiology of Depression? F.J.H. Tilders, E.D. Schmidt. Section IV: Effects of Cytokines and Cytokine Antagonists in Animal Models of Depression. 12. Anhedonic and Anxiogenic Effects of Cytokine Exposure; H. Anisman, Z. Merali. 13. Stress, Learned Helplessness, and Brain Interleukin-1&bgr;; S.F. Maier, et al. 14. Stress, Depression and the Role of Cytokines; B.E. Leonard, C. Song. Section V: Effects of Antidepressants on Cytokine Production and Action. 15. Is there Evidence for an Effect of Antidepressant Drugs on Immune Function? P.J. Neveu, N. Castanon. 16. Cytokines, `Depression Due to a General Medical Condition'', and Antidepressant Drugs; R. Yirmiya, et al. 17. Cytokines, Stress and Depression: Conclusion and Perspectives; R. Dantzer, et al. Index.