Death Receptors in Cancer Therapy by Wafik S. El-DeiryDeath Receptors in Cancer Therapy by Wafik S. El-Deiry

Death Receptors in Cancer Therapy

EditorWafik S. El-Deiry

Paperback | November 19, 2010

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An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

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Title:Death Receptors in Cancer TherapyFormat:PaperbackDimensions:388 pages, 10 × 7.01 × 0 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374016

ISBN - 13:9781617374012

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Table of Contents

Mammalian Cell Death Pathways: Intrinsic and ExtrinsicE. Robert McDonald III and Wafik S. El-DeiryResistance to Apoptosis in Cancer TherapyDavid J. McConkeyStructures of TNF Receptors and Their Interactions With LigandsSarah G. Hymowitz and Abraham M. de VosDeath Receptor Signaling in Embryonic Ectodermal DevelopmentPreet M. ChaudharyAdaptor Proteins in Death Receptor SignalingNien-Jung Chen and Wen-Chen YehCaspase Activation by the Extrinsic PathwayXiaolu YangDeath Signaling and Therapeutic Applications of TRAILMi-Hyang Kim and Dai-Wu SeolDeath Receptor MutationsSug Hyung Lee, Nam Jin Yoo, and Jung Young LeeRegulation of Death ReceptorsUdo Kontny and Heinrich KovarRegulation of TRAIL Receptor Expression in Human MelanomaPeter Hersey, Si Yi Zhang, and Xu Dong ZhangRegulation of Death Receptors by Synthetic RetinoidsShi-Yong SunRole of p53 in Regulation of Death ReceptorsRishu TakimotoProapoptotic Gene Silencing Via Methylation in Human TumorsTanya Tekautz, Tal Teitz, Jill M. Lahti, and Vincent J. KiddRegulation of Death Receptor-Induced Apoptosis by NF-kB and Interferon Signaling Pathways: Implications for Cancer TherapyRajani Ravi and Atul BediTRAIL in Cancer TherapyMahaveer Swaroop Bhojani, Brian D. Ross, and Alnawaz RehemtullaExpression and Regulation of Death Receptors in Multiple Myeloma and Prostate CarcinomaSubrata Ray, John G. Hissong, Marcela Oancea, and Alex AlmasanRegulation of TRAIL-Induced Apoptosis by Transcriptional FactorsRüdiger Göke and Youhai H. ChenSensitizing Tumor Cells by Targeting Death Receptor Signaling InhibitorsChristina Voelkel-JohnsonCeramide, Ceramidase, and FasL Gene Therapy in Prostate CancerJames S. Norris, David H. Holman, Marc L. Hyer, Alicja Bielawska, Ahmed El-Zawahry, Charles Chalfant, Charles Landen, Stephen Tomlinson, Jian-Yun Dong, Lina M. Obeid, and Yusuf HannunGene Therapy Targeting Receptor-Mediated Cell Death to CancersLidong Zhang and Bingliang FangCombination of Chemotherapy and Death Ligands in Cancer TherapySimone Fulda and Klaus-Michael DebatinIndex

Editorial Reviews

From the reviews:"The book is resourceful for both basic scientists and clinicians, who are interested in developing targeted therapies for cancer. . the book is a valuable tool for researchers as well as to those of us involved in teaching apoptosis to undergraduate and graduate students." (Harikrishna Nakshatri, Leukemia Research, 2005)