Deoxynucleoside Analogs in Cancer Therapy by Godefridus J PetersDeoxynucleoside Analogs in Cancer Therapy by Godefridus J Peters

Deoxynucleoside Analogs in Cancer Therapy

EditorGodefridus J Peters

Paperback | November 19, 2010

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Emerging as an important new volume in the renowned Cancer Drug Discovery and DevelopmentT series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics.Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers.Throughout Deoxynucleoside Analogs in Cancer Therapy, the focus is on novel aspects of deoxynucleoside analogs in the clinical context, as well as on unexpected targets of these compounds, such as their specific activity against cell cycle-dependent kinases or oncogenes. The wealth of information presented here can be used to design rational combinations aimed at inhibiting various cellular signaling pathways, or combining inhibition of various targets. Deoxynucleoside Analogs in Cancer Therapy has been designed specifically to facilitate such an interaction between various fields.
Title:Deoxynucleoside Analogs in Cancer TherapyFormat:PaperbackDimensions:490 pages, 9.02 × 5.98 × 0.07 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374970

ISBN - 13:9781617374975

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Table of Contents

Nucleoside Transport into Cells: The Role of Nucleoside Transporters SLC28 and SLC29 in Cancer ChemotherapyMarcal Pastor-Anglada and F. Javier CasadoThe Role of Deoxycytidine Kinase in DNA Synthesis and Nucleoside Analog ActivationMaria Staub and Staffan ErikssonDeoxynucleoside Kinases and Their Potential Role in Deoxynucleoside CytotoxicityBirgitte Munch-Petersen and Jure PiskurNucleotidases and Nucleoside Analog CytotoxicitySally Anne Hunsucker, Beverly S. Mitchell, and Jozef SpychalaPumping Out Drugs: The Potential Impact of ABC Transporters on Resistance to Base, Nucleoside, and Nucleotide AnalogsPiet Borst and Peter WielingaCytosine Arabinoside: Metabolism, Mechanisms, of Resistance, and Clinical PharmacologyIsabelle Hubeek, G. J. L. Kaspers, G Ossenkoppele, and G. J. PetersClofarabine: Mechanisms of Action, Pharmacology, and Clinical InvestigationVarsha Gandhi and William PlunkettL-Nucleosides as Chemotherapeutic AgentsGiuseppe Gumina, Youhoon Chong, and Chung K. ChuTroxacitabine: A Deoxycytidine Nucleoside Analogue With Potent Antitumor ActivityHenriette Gourdeau and Jacques Jolivet9-b-D-arabinofuranosylguanineSophie CurboGemcitabine: Mechanism of Action and ResistanceA. M. Bergman and G.J. PetersClinical Activity of Gemcitabine as a Single Agent and in CombinationJ. R. Kroep, GJ Peters, and RA NagourneyNucleoside RadiosensitizersDonna S. Shewach and Theodore S. LawrenceNONMEM Population Models of Cytosine Arabinoside and Flubaradine Phosphate in Pediatric Patients with Leukemia Vassilios I. AvramisThe cycloSal-Nucleotide Delivery System: Development of Chemical Trojan Horses as Antiviral AgentsChris Meier, Jan Balzarini, and Astrid MeerbachPurine and Pyrimidine Based Analogs and Suicide Gene TherapyZoran Gojkovic3'-deoxy-3'- Fluorothymidine as a Tracer if Proliferation in Positron Emission Tomography

Editorial Reviews

"...a top-notch overview of the current knowledge in the area of deoxynucleoside analog development and application in the treatment of cancer."  -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal "...an excellent book that is suitable for researchers or clinicians with an interest in deoxynucleoside analgos and/or cancer chemotherapy."  -Weighted Numerical Score: 92 - 4 Stars!-Doody's Health Science Book Review Journal