Depression and its treatment: A translational approach by Carmine ParianteDepression and its treatment: A translational approach by Carmine Pariante

Depression and its treatment: A translational approach

EditorCarmine Pariante

Paperback | July 1, 2009

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Depression is a major cause of morbidity throughout the world. Given that between 8 and 12% of the population (in most countries) will suffer from depression at some point in their lives, it is clearly a significant public health problem. As our knowledge of this illness has expanded in recentyears, it has become clear that depression can no longer be viewed as a simple disorder of the brain. It has to be seen as a series of behavioural and biological changes that span mind, brain, genes, and body - indeed affecting both psychological and physical health. This book brings together world leaders in research on depression, to discuss, for the first time, in an interdisciplinary setting, both classical and innovative ideas to understand this devastating disorder. It presents neurobiological, psychological, genetic and evolutionary models, with aparticular emphasis on the mechanisms linking the brain to the endocrine and the immune systems, and therefore linking depression to physical health. Opening with a powerful, personal, account of depression, that conveys something of the all-consuming, debilitating, nature of this illness, the book then presents cutting edge research from those at the frontiers of work in this area. The book will be valuable for all those in the brain sciencesseeking a state of the art review of this global problem.
Dr. Carmine Pariante is with the Institute of Psychiatry.
Title:Depression and its treatment: A translational approachFormat:PaperbackDimensions:304 pages, 9.69 × 6.73 × 0.04 inPublished:July 1, 2009Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199533075

ISBN - 13:9780199533077


Table of Contents

1. Lewis Wolpert: Experiencing depression2. Monica Kelly Cowles, Carmine Pariante and Charles B Nemeroff: Depression in the medically ill3. Randolph M Nesse: Explaining depression: neuroscience is not enough, evolution is essential4. Bernard J Crespi: Evolutionary genetics of affective disorders5. Stephan Claes, Elisabeth B Binder and Charles B Nemeroff: Genetic factors in stress and major depression6. Daniel J Smith, Michael J Owen and Nick Craddock: Bipolar disorder and unipolar depression: what is the genetic relationship?7. Becky Conway-Campbell, C C Wiles and Stafford Lightman: The significance of dysregulated basal glucocorticoid pulsatility in affective disorders8. Caitlin S Wyrwoll, Megan C Holmes and Jonathan R Seckl: Early life programming of affective function9. Sabine Chourbaji and Peter Gass: Modeling depression by GR mutant animals?10. Robert Dantzer, Jason C O'Connor, Nathalie Castanon, Jacques Lestage and Keith W Kelley: Cytokines and depression: experimental evidence and intermediate mechanisms11. Paul Lucassen, Peter Meerlo, A S Naylor, A M van Dam, A G Dayer, B Czeh and C A Oomen: Do depression, stress, sleep disruption and inflammation alter hippocampal apoptosis and neurogenesis?12. Steven F Maier, Jose Amat, Michael V Baratta, Sondra T Bland, John C Christianson, Brittany Thompson, Robert R Rozeske and Linda R Watkins: The role of the medial prefrontal cortex in mediating resistance and vulnerability to the impact of adverse events13. Philip J Cowen and C J Harmer: Is it all monoamines?14. Nicole Geschwind, Jim van Os, Frenk Peeters and Marieke Wichers: The role of affective processing in vulnerability to and resilience against depression15. Elizabeth Young: PTSD and HPA axis: same hormones, different disorders16. Timothy G Dinan and Peter Fitzgerald: Neuroendocrine and immune cross talk in major depression17. Andrew H Miller, Thaddeus W W Pace and Charles I Raison: Neuropsychiatric effects of IFN-alpha: relevance to depression18. Andrew Steptoe: Depression and coronary heart disease19. Tony Cleare: Does depression induce pain and fatigue?20. Matthew Hotopf and Max Henderson: Explaining the association between depression and mortality: a life course epidemiology approach21. Allan H Young: Depression: unipolar or bipolar, what's the difference (and what does it matter anyway)?22. Matthew T Keener and Mary L Phillips: Can neuroimaging help distinguish bipolar depression from major depressive disorder?23. Bhanu Gupta, Robert Keers, Rudolf Uher, Peter McGuffin and Katherine J Aitchison: Pharmacogenetics of antidepressant response24. R Hamish McAllister-Williams and Grzegorz Wisniewski: Can the EEG be used to predict antidepressant response?25. Thomas E Schlaepfer and Bettina Bewernick: Can we use magnetic/electric fields to help in treatment resistant depression?26. Sarah E Gartside, K S Reid and I Nicol Ferrier: Antiglucocorticoids in the treatment of affective disorders: from pre-clinical to clinical studies27. David Nutt and Christoher A Lowry: How can we use current knowledge to improve antidepressant treatments?