Design of Enzyme Inhibitors as Drugs, Volume 2

Hardcover | April 1, 1995

EditorMerton Sandler, H. John Smith

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Outlining the latest developments in the design of enzyme inhibitors as potent drugs in the treatment of disease and infection, Volume 2 extends on the previous volume in providing a comprehensive coverage of more recently recognised target enzymes and their known inhibitors. It demonstrates how the drug designer uses all available information to develop a specific therapeutic agent. The text outlines the steps involved in developing these drugs - from initial inception to satisfactory marketing - a process thwart with potential difficulties and involving the skills ofchemists, biochemists, pharmacologists, and clinicians.A fascinating insight into the world of drug development, this second volume will certainly maintain the position as the text in this field.

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Outlining the latest developments in the design of enzyme inhibitors as potent drugs in the treatment of disease and infection, Volume 2 extends on the previous volume in providing a comprehensive coverage of more recently recognised target enzymes and their known inhibitors. It demonstrates how the drug designer uses all available in...

Merton Sandler, Professor of Chemical Pathology, Royal Postgraduate Medical School, University of London. H. John Smith, Senior Lecturer in Medicinal Chemistry, Welsh School of Pharmacy, University of Wales College of Cardiff.
Format:HardcoverDimensions:848 pages, 9.21 × 6.14 × 0.01 inPublished:April 1, 1995Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0192621343

ISBN - 13:9780192621344

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Table of Contents

Preface1. Enzyme inhibitors as drugs: from design to the clinic2. Computer-aided molecular design of enzyme inhibitors3. Protein serine - threonine kinases4. Inhibitors of protein tyrosine kinases5. Inhibitors of non-protein kinases6. Enzyme targets as an approach to therapy for HIV infections7. Inhibitors of viral DNA Polymerase8. Fungal enzyme targets9. Steroidogenesis pathway enzymes10. HMG-Co A reductase inhibitors11. DNA topoisomerases12. Catecholamine - O- methyltrasnferase (COMT) and COMT inhibitors13. Inhibitors of Phospholipase A14. Inhibitors of gastric H+, K+ ATPase15. Inhibitors of mammalian collagenases16. Inhibitors of Aldose Reductase17. Miscellaneous topics