Desmoid Tumors by Charisse LitchmanDesmoid Tumors by Charisse Litchman

Desmoid Tumors

byCharisse Litchman

Hardcover | August 31, 2011

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Desmoid Tumors (DT), also called Aggressive Fibromatoses, are a rare fibroblastic proliferative disease, with an incidence of 2 to 4 new cases per million people per year. Despite the absence of a metastatic potential, DT cause significant morbidity and at times mortality due to its locally invasive behaviour. The anatomical locations can be abdominal, extra-abdominal (often in the extremities) and intra-abdominal. This book is the first manuscript dedicated entirely to Desmoid Tumors. Written by prominent clinicians, researchers and advocacy group experts, patients and professionals alike will find this to be a comprehensive review. Clinical presentation, imaging guidelines and treatment paradigms are highlighted. Both the sporadic and heredity forms (Familial Adenomatous Polyposis) will be discussed. A thorough discussion on the unique issues in children with DT is included. A portion of the book will address the role of the APC gene, the β-catenin protein and the role of mutations in the genesis of DT. Emerging cutting edge research techniques will be revealed. Also included is a thoughtful discussion on the controversial labelling of Desmoid Tumors as benign and the consequences of such a designation. The role of advocacy groups in supporting research and in promoting awareness of rare diseases such as DT will be outlined. This book will serve as basis to prepare clinicians, researchers and patients to embark on the quest for a cure for Desmoid Tumors.
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Title:Desmoid TumorsFormat:HardcoverDimensions:221 pagesPublished:August 31, 2011Publisher:Springer NatureLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9400716842

ISBN - 13:9789400716841

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Table of Contents

1. Introduction.- Part I  The identification and treatment of Desmoid Tumors.- 2. Clinical presentation of Desmoid Tumors.- 3.  Pathology of Desmoid Tumors.- 4.  APC/ ?-catenin degeneration in Desmoid Tumors: important   implications for diagnosis, prognosis, and therapy.- 5. Imaging Techniques in Desmoid Tumors.- 6. Surgical management of DesmoidTumors.- 7. Systemic Therapy of Desmoid Tumors.- 8.  Radiation Therapy for Desmoid Tumors.- 9.  Interventional Radiology.- Part 2  Special Populations with Desmoid Tumors.- 10. Desmoid Disease in Familial Adenomatous Polyposis.- 11. Desmoid Tumor in Children and Adolescents: The Influence of Age.- Part 3  Considerations for current and future advancement in the search for a cure.- 12.  Microarrays and High-Throughput Sequencing in Desmoid Type Fibromatosis and Scar.- 13. Desmoid Tumors: Are they benign or malignant?- 14. The Role of Advocacy Groups in Rare Tumors such as Desmoid Tumors.- Index.