Diagnostic, Prognostic and Therapeutic Value of Gene Signatures by Antonio RussoDiagnostic, Prognostic and Therapeutic Value of Gene Signatures by Antonio Russo

Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

byAntonio RussoEditorStefano Iacobelli, Juan Iovanna

Hardcover | November 2, 2011

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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors.


Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors.


Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.

Title:Diagnostic, Prognostic and Therapeutic Value of Gene SignaturesFormat:HardcoverDimensions:182 pagesPublished:November 2, 2011Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617793574

ISBN - 13:9781617793578

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Table of Contents


Chapter 1 Gene signatures and soft tissue sarcomas: status of art and perspectives

Bruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe Tonini

Chapter 2 Heterogeneity of breast cancer: gene signatures and beyond

Gaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. Martens

Chapter 3 Gene signatures in CRC and liver metastasis

Daniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio Russo

Chapter 4 Gene signatures in Gastrointestinal Stomal Tumors (GIST)

Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybyl, and Maria Debiec-Rychter

Chapter 5 Pancreatic Cancer Genetics

Juan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson Dusetti

Chapter 6 Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancer

Rafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia Wei

Chapter 7 Gene signatures in Gastric Cancer

Laura Ottini, Mario Falchetti, and Gabriella Nesi

Chapter 8 Gene signatures in Colorectal Cancer

Alessandro Lugli and Inti Zlobec

Chapter 9 The role of epigenetics in cancer: from molecular function to high-throughput assays

Aleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore Spicuglia

Chapter 10 Primary Epithelial Ovarian Neoplasms:  New concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studies

Bernard Czernobilsky, Leonor Leider-Trejo, and Antonio Russo

Chapter 11 Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patterns

Umberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone

Editorial Reviews

From the reviews:"This is a useful compendium of various molecular methods (with a special focus on microarray technology) applied to research and diagnostic and prognostic purposes for most solid human tumors . . The book is designed primarily for residents and fellows, oncologists, pathologists, molecular biologists, biotechnologists, and others who study oncologic diseases. . chapters are detailed and informative and present molecular genetic aspects in an appropriate clinical setting. . The references following each chapter are extensive, relevant, and updated." (Semir Vranic, Doody's Review Service, July, 2012)