Diagnostic, Prognostic and Therapeutic Value of Gene Signatures by Antonio RussoDiagnostic, Prognostic and Therapeutic Value of Gene Signatures by Antonio Russo

Diagnostic, Prognostic and Therapeutic Value of Gene Signatures

EditorAntonio Russo, Stefano Iacobelli, Juan Iovanna

Hardcover | November 2, 2011

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Gene expression studies have revealed diagnostic profiles and upregulation of specific pathways in many solid tumors. The explosion of new information in gene expression profiling could potentially lead to the development of tailored treatments in many solid tumors. In addition many studies are ongoing to validate these signatures also in predicting response to hormonal, chemotherapeutic and targeted agents in breast cancer as well as in other tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures provides readers a useful and comprehensive resource about the range of applications of microarray technology in oncological diseases. Topics covered include gene signatures and soft tissue sarcomas, prognostic relevance of breast cancer signatures, gene expression profiling of colorectal cancer and liver metastasis, gene signatures in GISTs, CNVs and gene expression profiles in pancreatic cancer, and gene signatures in head/neck, lung and gastric tumors. Diagnostic, Prognostic and Therapeutic Value of Gene Signatures will be of great value to residents and fellows, physicians, pathologists and  medical oncologists.
Title:Diagnostic, Prognostic and Therapeutic Value of Gene SignaturesFormat:HardcoverDimensions:193 pagesPublished:November 2, 2011Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617793574

ISBN - 13:9781617793578

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Table of Contents

PrefaceChapter 1 Gene signatures and soft tissue sarcomas: status of art and perspectivesBruno Vincenzi, Anna Maria Frezza, Daniele Santini, and Giuseppe ToniniChapter 2 Heterogeneity of breast cancer: gene signatures and beyondGaia Schiavon, Marcel Smid, Gaorav P. Gupta, Stefania Redana, Daniele Santini, and John W.M. MartensChapter 3 Gene signatures in CRC and liver metastasisDaniele Fanale, Lidia Corsini, Sergio Rizzo, and Antonio RussoChapter 4 Gene signatures in Gastrointestinal Stomal Tumors (GIST)Piotr Rutkowski, Giuseppe Badalamenti, Laura La Paglia, Joanna Przybyl, and Maria Debiec-RychterChapter 5 Pancreatic Cancer GeneticsJuan Iovanna, Ezequiel Luis Calvo, Jean Charles Dagorn, and Nelson DusettiChapter 6 Diagnostic, prognostic and therapeutic value of gene signatures in non-small-cell lung cancerRafael Rosell, Miquel Taron, Christian Diego Rolfo, Delvys Rodriguez-Abreu, and Jia WeiChapter 7 Gene signatures in Gastric CancerLaura Ottini, Mario Falchetti, and Gabriella NesiChapter 8 Gene signatures in Colorectal Cancer Alessandro Lugli and Inti ZlobecChapter 9 The role of epigenetics in cancer: from molecular function to high-throughput assaysAleksandra Pekowska, Joaquin Zacarias-Cabeza, Jinsong Jia, Pierre Ferrier, and Salvatore SpicugliaChapter 10 Primary Epithelial Ovarian Neoplasms:  New concepts concerning origin, pathogenesis and classification based on morphology, immunomarkers, molecular features and gene expression studiesBernard Czernobilsky, Leonor Leider-Trejo, and Antonio RussoChapter 11 Thyroid carcinoma: molecular signature by histotype specific mutations and gene expression patternsUmberto Malapelle, Claudio Bellevicine, Lajos Pustzai, and Giancarlo Troncone

Editorial Reviews

From the reviews:"This is a useful compendium of various molecular methods (with a special focus on microarray technology) applied to research and diagnostic and prognostic purposes for most solid human tumors . . The book is designed primarily for residents and fellows, oncologists, pathologists, molecular biologists, biotechnologists, and others who study oncologic diseases. . chapters are detailed and informative and present molecular genetic aspects in an appropriate clinical setting. . The references following each chapter are extensive, relevant, and updated." (Semir Vranic, Doody's Review Service, July, 2012)