Discrete Event Simulation For Health Technology Assessment by J. Jaime CaroDiscrete Event Simulation For Health Technology Assessment by J. Jaime Caro

Discrete Event Simulation For Health Technology Assessment

byJ. Jaime Caro, Jörgen Möller, Jonathan Karnon

Hardcover | October 16, 2015

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Discover How to Apply DES to Problems Encountered in HTA

Discrete event simulation (DES) has traditionally been used in the engineering and operations research fields. The use of DES to inform decisions about health technologies is still in its infancy. Written by specialists at the forefront of this area,Discrete Event Simulation for Health Technology Assessmentis the first book to make all the central concepts of DES relevant for health technology assessment (HTA). Accessible to beginners, the book requires no prerequisites and describes the concepts with as little jargon as possible.

The book first covers the essential concepts and their implementation. It next provides a fully worked out example using both a widely available spreadsheet program (Microsoft Excel) and a popular specialized simulation package (Arena). It then presents approaches to analyze the simulations, including the treatment of uncertainty; tackles the development of the required equations; explains the techniques to verify that the models are as efficient as possible; and explores the indispensable topic of validation. The book also covers a variety of non-essential yet handy topics, such as the animation of a simulation and extensions of DES, and incorporates a real case study involving screening strategies for breast cancer surveillance.

This book guides you in leveraging DES in your assessments of health technologies. After reading the chapters in sequence, you will be able to construct a realistic model designed to help in the assessment of a new health technology.

J. Jaime Caro, MDCM, FRCPC, FACP, is an adjunct professor of medicine as well as epidemiology and biostatistics at McGill University. He also teaches discrete event simulation (DES) at Thomas Jefferson University School of Population Health and is chief scientist at Evidera. He founded the Caro Research Institute, chaired the Modeling ...
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Title:Discrete Event Simulation For Health Technology AssessmentFormat:HardcoverDimensions:374 pages, 9.5 × 6.25 × 1 inPublished:October 16, 2015Publisher:Taylor and FrancisLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1482218240

ISBN - 13:9781482218244

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Table of Contents

Introduction
The HTA Context
What Is Discrete Event Simulation?
How Does DES Compare to Other Techniques Commonly Used in HTA?
When Is Discrete Event Simulation Useful?
Acceptance of Discrete Event Simulation

Central Concepts
Events
Event Occurrence
Entities
Attributes
Time
Resources and Queues
Global Information
Distributions
Using Influence Diagrams

Implementation
Control Logic
Using Distributions
Event Handling
Specifying Events
Creating the Population
Assigning Attributes
Handling Time
Applying Intervention Effects
Recording Information
Reflecting Resource Use

A Simple Example
Design
Obtaining the Inputs
Structuring the Model
Obtaining Results

Analyses
Base Case
Exploring Sensitivity to Input Values

Formulating the Required Equations
Requirements for the Equations
Selecting Data Sources
Taxonomy of Equation Types Commonly Used in DES
Selection of Predictors
Validation of the Final Equation
Combining Inputs and Equations from Different Sources

Efficiency and Variance Reduction
Reducing Unwanted Variance
Other Efficiency Improvements
Settings Affecting Model Execution

Validation
Face Validity
Verification
External Validation

Special Topics
Documentation
Animation
Software
Agent-Based Models
Hybrid Models

Case Study: Breast Cancer Surveillance
Background
Why DES?
Design
Data Sources
Implementation
Analyses
Results
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