Disorders of Synaptic Plasticity and Schizophrenia

Other | May 1, 2004

bySmythies, John, John Smythies

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Schizophrenia is a severe brain disorder that affects 1% of the population. Its cause is due to the interaction of a number of abnormal genes with environmental factors. This book summarizes new advances schizophrenia research that focus on the field of neural and synaptic plasticity. Synapses in the brain in schizophrenia show a wide range of disorders, both structural and functional. This volume covers the most active and promising of these new developments, and opens up new avenues for the treatment of schizophrenia.

* Addresses new areas of research in neurotransmitters, receptors, vitamin transport, metabolism, and signaling.
* Reviews the growing field of synaptic plasticity research
* Provides links with other diseases of the Central Nervous System (CNS)

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Schizophrenia is a severe brain disorder that affects 1% of the population. Its cause is due to the interaction of a number of abnormal genes with environmental factors. This book summarizes new advances schizophrenia research that focus on the field of neural and synaptic plasticity. Synapses in the brain in schizophrenia show a wide ...

John Smythies is a neuropsychiatrist and neuroscientist and has made significant contributions to both these disciplines. Together with Humphrey Osmond he developed the first biochemical theory of schizophrenia-the transmethylation hypothesis. This has recently come back into focus following the finding that DNA methylation is abnormal...

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Format:OtherDimensions:542 pages, 1 × 1 × 1 inPublished:May 1, 2004Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080548628

ISBN - 13:9780080548623

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Table of Contents

Loss of Spines and Neuropil; Schizophrenia as a Disorder of Neuroplasticity; The Synaptic Pathology of Schizophrenia: Is Aberrant Neurodevelopment and Plasticity to Blame?; Neurochemical Basis for an Epigenetic Vision of Synaptic Organization; Muscarinic Receptors in Schizophrenia - Is There a Role for Synaptic Plasticity?; Serotonin and Brain Development; Presynaptic Proteins and Schizophrenia; Mitogen-Activated Protein Kinase Signaling; Postsynaptic Density Scaffold Proteins at Excitatory Synapse and Disorders of Synaptic Plasticity: Implications for Human Behavior Pathologies; Prostaglandin Mediated Signaling in Schizophrenia; Mitochondria, Synaptic Plasticity, and Schizophrenia; Membrane Phospholipids and Cytokine Interaction in Schizophrenia; Neurotensis, Schizophrenia and Antipsychotic Drug Action; Schizophrenia, Vitamin D and Brain Development; Possible Contributions of Myelin and Oligodendrocyte Dysfunction to Schizophrenia; Brain Derived Neurotrophic Factor and the Plasticity of the Mesolimbic Dopamine Pathway; S100B in Schizophrenic Psychosis; Oct-6 Transcription Factor; NMDA Receptors, Synaptic Plasticity and Schizophrenia