DNA Methylation, Epigenetics and Metastasis by Manel EstellerDNA Methylation, Epigenetics and Metastasis by Manel Esteller

DNA Methylation, Epigenetics and Metastasis

EditorManel Esteller

Paperback | October 22, 2010

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This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.
Title:DNA Methylation, Epigenetics and MetastasisFormat:PaperbackDimensions:322 pagesPublished:October 22, 2010Publisher:Springer NetherlandsLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9048169178

ISBN - 13:9789048169177

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Table of Contents

Chapter 1: How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes. Manel EstellerChapter 2: A Mouse Skin Multistage Carcinogenesis Model that Unmasks Epigenetic Lesions Responsible for Metastasis. Mario F. Fraga & Manel EstellerChapter 3: CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis. Ubaradka G. Sathyanarayana & Adi F. GazdarChapter 4: CpG Island Hypermethylation Changes During Prostate Cancer Progression and Metastasis. Srinivasan Yegnasubramanian & William G. NelsonChapter 5: CpG Island Hypermethylation in Breast Cancer Progression and Metastasis. Paola ParrellaChapter 6: Epigenettic Dysregulation of Maspin (SerpinB5) in Cancer Invasion and Metastasis. Bernard W. Futscher & Frederick E. DomannChapter 7: Epigenetic Regulation of the E-cadherin Cell-Cell Adhesion Gene. Hector Peinado & Amparo CanoChapter 8: Epigenetic Disruption of the SLIT-ROBO Interactions in Human Cancer. Ashraf Dallol, Rachel E. Dickinson & Farida LatifChapter 9: Molecular Mechanisms of the Metastasis-Associated Gene Family of Coregulators: Role in Cancer and Invasion. Seetharaman Balasenthil & Rakesh KumarChapter 10: The Molecular Mechanisms for BRMS1 Action in Cancer Metastasis. Rajeev S. Samant & Lalita A. ShevdeChapter 11: Mechanisms of DNA Demethylating Drugs Against Cancer Progression. Zunyan Dai, Kavitha Kosuri & Gregory A. OttersonChapter 12: Histone Deacetylase Inhibitors: Novel Targeted Anti-Cancer Agents. Paul Marks & William Kevin Kelly.