Dna Modifications In The Brain: Neuroepigenetic Regulation Of Gene Expression

Paperback | January 5, 2017

byTimothy W Bredy

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DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Provides a comprehensive overview of the many facets of DNA modifications Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels Contains contributions by influential leaders in the field Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

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From the Publisher

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both n...

Dr. Timothy Bredy is Associate Professor of Neuroscience in the Ayala School of Biological Sciences at the University of California Irvine and Senior Research Fellow within the Queensland Brain Institute at the University of Queensland.
Format:PaperbackDimensions:150 pages, 8.75 × 6.35 × 0.68 inPublished:January 5, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128015969

ISBN - 13:9780128015964

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Table of Contents

1. History of DNA modifications in the brain

2. Approaches to detecting DNA base modification in the brain

3. Active DNA Demethylation in Neurodevelopment

4. Tet and 5hmC in neurodevelopment and the adult brain

5. Beyond mCG: DNA Methylation in Non-Canonical Sequence Context

6. DNA modifications and memory

7. New approaches to detecting DNA base modifications in the brain

8. DNA modifications and neuropsychiatric disease

9. What does the future hold for the study of nucleic acid modifications in the brain?