DNA-Protein: Structural Interactions

Paperback | September 1, 1994

EditorDavid M. J. LilleyAs told byLilley

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Many processes in the genetic life of the cell requires the specific interaction between proteins and DNA. While DNA is normally thought of as a straight double helix, it can be distorted by bending and twisting, and these alterations are critical to a number of cellular processes. Theseinclude transcription (by which the genetic message is read), recombination (rearrangements by which new combinations of genes come about), and the repair of DNA damage. An interesting group of the proteins have the important role of recognising and manipulating DNA structure. This book drawstogether themes from different parts of molecular biology to bring out the importance of DNA structure in the interactions between proteins and DNA, and generates a new perspective on DNA-protein interactions.

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From the Publisher

Many processes in the genetic life of the cell requires the specific interaction between proteins and DNA. While DNA is normally thought of as a straight double helix, it can be distorted by bending and twisting, and these alterations are critical to a number of cellular processes. Theseinclude transcription (by which the genetic messa...

David M. J. Lilley is at CRC Nucleic Acid Structure Research Group.

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Format:PaperbackDimensions:214 pages, 9.69 × 7.44 × 0.51 inPublished:September 1, 1994Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:019963453X

ISBN - 13:9780199634538

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Table of Contents

1. DNA-protein interaction at high resolution2. DNA bending by sequence and proteins3. Enzymes that supercoil DNA4. Recognition of DNA damage and repair5. Structure-recognition by DNA junction resolving enzymes6. Site-specific recombinases and their interactions with DNA7. The HMG-box domain

Editorial Reviews

"ÝT¨he reader is left with a deep appreciation for the structural and mechanistic possibilities that have emerged from the long co-evolution of DNA and DNA-binding proteins."--Quarterly Review of Biology