DNA Repair in Cancer Therapy by Lawrence C. PanasciDNA Repair in Cancer Therapy by Lawrence C. Panasci

DNA Repair in Cancer Therapy

EditorLawrence C. Panasci, Moulay A. Alaoui-Jamali

Paperback | November 19, 2010

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A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.
Title:DNA Repair in Cancer TherapyFormat:PaperbackDimensions:374 pages, 9.02 × 5.98 × 0 inPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374806

ISBN - 13:9781617374807

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Table of Contents

Clinical Resistance to Alkylators: Status and PerspectiveBrian Leyland-JonesRole of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking AgentsLawrence C. Panasci, Zhi-Yuan Xu, and Raquel AloyzRepair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic DrugsPeter J. McHugh and John A. HartleyChemosensitization to Platinum-Based Anticancer Drugs: Current Trends and Future ProspectsBertrand J. Jean-ClaudeRegulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor CellsIstvan Boldogh, Kishor K. Bhakat, Dora Bocangel, Gokul C. Das, and Sankar MitraStress-Activated Signal Transduction Pathways in DNA Damage Response: Implications for Repair, Arrest, and Therapeutic InterventionsMoulay A. Alaoui-Jamali, P. James Scrivens, and Martin LoignonOvercoming Resistance to Alkylating Agents by Inhibitors of O6-Alkylguanine-DNA AlkyltransferaseAnthony E. Pegg and M. Eileen DolanCellular Protection Against the Antitumor Drug BleomycinDindial Ramotar, Huijie Wang, and Chaunhua HePotential Role of PARP Inhibitors in Cancer Treatment and Cell DeathMichèle Rouleau and Guy G. PoirierRelationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to RadiotherapyDavid Murray and Adrian C. BeggStrand-Break Repair and Radiation ResistanceGeorge ShenoudaV(D)J Recombination and DNA Double-Strand-Break Repair: From Immune Deficiency to TumorigenesisDespina Moshous and Jean-Pierre de VillartayInherited Disorders of Genomic Instability and Cancer SusceptibilityGary M. KupferRole of BRCA1 and BRCA2 in DNA Repair and Potential Impact on TherapeuticsRazqallah HakemGenetic Variations in DNA Repair: Their Implications in Human Cancer Risk, Prevention, and TherapyJennifer J. HuIndex

Editorial Reviews

...gives a comprehensive review of the modern status of the DNA repair field for cancer researchers and clinical practitioners and provides a solid basis for in-depth study of different areas in this field...The book is a timely publication with a significant intended audience that will be served well. The book is well planned, well written, comprehensive, and addresses recent findings in the field. -Doody's Health Sciences Book Review Journal"...extensive and extremely detailed...a comprehensive review of DNA repair." - The Annals of Pharmacotherapy"Comprehensive and cutting-edge, for both cancer researchers and practicing oncologists dealing with the hallmark 'relapse; or 'drug resistance' phenomena on a daily basis...." Tumori