Drug Delivery: Engineering Principles for Drug Therapy

Hardcover | February 15, 2001

byW. Mark Saltzman

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Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding ofthe principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporarybiomaterials.

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Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding ofthe principles that govern rates of drug tra...

W. Mark Saltzman is at Cornell University.

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Format:HardcoverPublished:February 15, 2001Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195085892

ISBN - 13:9780195085891

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Table of Contents

Part I. Introductory material1. Introduction2. Drug administration and drug effectivenessPart II. Fundamentals3. Diffusion and drug dispersion4. Diffusion in biological systems5. Drug permeation through biological barriers6. Drug transport by fluid motion7. Pharmacokinetics of drug distributionPart III. Drug delivery systems8. Drug modification9. Controlled drug delivery systems10. Case studies in drug delivery11. PostscriptAppendix A. Overview of polymeric biomaterialsA1. Nondegradable polymersA2. Biodegradable polymersA3. Water-soluble polymersAppendix B. Useful data and nomenclatureB1. Physiological parametersB2. Cardiovascular systemB3. Clinical chemistryB4. Permeation and diffusionB5. Protein propertiesB6. Mathematical tables and functionsB7. NomenclatureIndex

Editorial Reviews

"[A]n excellent addition to the library of any scientist interested in drug delivery systems. Unlike others in the area, this volume is focused on quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological conditions. ... evena scientist who may lack a background in mathematics could benefit from this unique discussion of engineering concepts. ... what makes this book outstanding is the ability of the author to discus mathematical equations grounded in real examples. ... The book is highly recommended as a textbook inthe field of drug delivery ..."--The Quarterly Review of Biology