Drug Development: Molecular Targets for GI Diseases by Timothy S. GaginellaDrug Development: Molecular Targets for GI Diseases by Timothy S. Gaginella

Drug Development: Molecular Targets for GI Diseases

byTimothy S. GaginellaEditorAntonio Guglietta

Paperback | November 5, 2010

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Timothy Gaginella and Antonio Guglietta bring together hands-on experts to critically review the many promising new areas of gastrointestinal pharmacology at the molecular level. Key chapters discuss such major themes as cyclooxygenase-2 inhibitors, the complexities of nitric oxide pathways in the gut, and the influence of cytokines on inflammatory bowel disease, as well as new opportunities for pharmacotherapy, including peptide growth factors, achykinins-particularly substance P and neurokinins-cholecystokinin receptors, and serotonin. Also examined as possible sites for treating motility disorders and visceral pain are the opioid receptors residing in the gut, and the H3-receptor agonists for treating gut inflammation and pain. Drug Development: Molecular Targets for Gastrointestinal Disease provides a comprehensive review of today's molecular pharmacological approaches to the discovery and development of novel drugs for gastrointestinal and liver diseases.
Title:Drug Development: Molecular Targets for GI DiseasesFormat:PaperbackDimensions:278 pages, 22.9 × 15.2 × 0.01 inPublished:November 5, 2010Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617370878

ISBN - 13:9781617370878

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Table of Contents

The Arachidonic Acid Pathway: New Molecules and Enzymes, John L. Wallace. Therapeutic Implications of the Nitric Oxide Pathway in Gastrointestinal Diseases, B. L. Tepperman and B. J. R. Whittle. Cytokines: Opportunities for Therapeutic Intervention, Alan D. Levine and Claudio Fiocchi. Peptide Growth Factors in Gastrointestinal Disorder Therapeutics, Antonio Guglietta and Marija Veljaca. Tachykinins: From Basic Concepts to Therapeutic Implications, Peter Holzer. CCKA Receptors in Gastrointestinal Disorders: New Therapeutic Implications, Massimo D'Amato, Francesco Makovec, and Lucio C. Rovati. 5-HT3/5-HT4 Receptors in Motility Disorders: New Therapeutic Agents, Sushil K. Sarna, Michel R. Briejer, and Jan A. J. Schuurkes. Opioid Receptors: Targets for New Gastrointestinal Drug Development, Pierre J. M. Rivière and Jean-Louis Junien. The Histamine H3 Receptor: Pharmacotherapy Targets in Gastrointestinal Disorders, Gabriella Coruzzi, Enzo Poli, Giuseppina Morini, and Giulio Bertaccini. Index.

Editorial Reviews

"The book focuses on specific molecules and the drugs that act on them, their receptors, metabolism or synthesis. . . a useful text for investigators of GI function and for pharmacologists interested in therapeutic compounds, their actions and targets."-Trends in Pharmaceutical Sciences