Drug-Drug Interactions: Scientific and Regulatory Perspectives

Hardcover | October 2, 1997

byAlbert P. AugustEditorFerid Murad, M. W. Anders

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DrugDrug Interactions is a comprehensive review of the scientific and regulatory perspectives of drugdrug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drugdrug interactions, the prediction of drugdrug interaction potential of new drugs, and the avoidance of clinically significant drugdrug interaction in patients. Key Features* Provides useful references on the science of drug-drug interactions* Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint* Contains original data from academic and industrial laboratories* Presents an overview of regulatory agency positions

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From the Publisher

DrugDrug Interactions is a comprehensive review of the scientific and regulatory perspectives of drugdrug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of int...

From the Jacket

Praise for the Series"Recommended not only to pharmacologists but also to all those in related disciplines."--NATURE"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, conc...

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held ...

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Format:HardcoverDimensions:304 pages, 9 × 6 × 0.98 inPublished:October 2, 1997Publisher:Academic Press

The following ISBNs are associated with this title:

ISBN - 10:0120329441

ISBN - 13:9780120329441

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Table of Contents

J. Collins, Foreword.
A.P. Li, Preface.
A.P. Li, Overview: Scientific Basis of Pharmacokinetic Drug-Drug Interactions.
F.P. Guengerich, Role of Cytochrome P450 Enzymes in Drug-Drug Interactions.
J.M. Sauer, E.R. Stine, L. Gunawardhana, D.A. Hill, and I.G. Sipes, The Liver as a Target for Chemical-Chemical Interactions.
A.D. Rodrigues and S.L. Wong, Applications of Human Liver Microsomes in Metabolism-Based Drug-Drug Interactions.
A.P. Li, Applications of Human Hepatocytes as an Experimental System for the Evaluation of Pharmacokinetic Drug-Drug Interactions.
J.L. Ferrero and K. Brendal, Liver Slices as a Model in Drug Metabolism and Drug-Drug Interactions.
C.L. Crespi and B.W. Penman, The Use of cDNA Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions.
G.L. Kedderis, Pharmacokinetics of Drug Interactions.
T.N. Thompson, Experimental Models for Evaluating Enzyme Induction Potential of New Drug Candidates in Animals and Man and a Strategy for Their Use.
J.D. Balian, Metabolic Drug-Drug Interactions: Perspective from U.S. FDA Medical and Clinical Pharmacology Reviewers.
M. Jurima-Romet, Drug Interactions: Perspectives of the Canadian Directorate.

Editorial Reviews

Praise for the Series"Recommended not only to pharmacologists but also to all those in related disciplines."--NATURE"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated."--H.E. Kaufmann in CHEMOTHERAPY"Superb reading material."--JOURNAL OF PHARMACEUTICAL SCIENCES"This book represents a comprehensive review of drug-drug interaction and is unique since the contributors are from all facets of the workplace, including academic institutes, government, and industry... The most attractive feature of the book is its well-focused subject area with the emphasis on the importance of P-450 enzymes in drug interactions and how government regulatory agencies evaluate them... It is unique since it presents the regulatory aspects of drug evaluations as an integral part of the science of drug-drug interactions."--Rajendar Mehta, PhD, University of Illinois at Chicago College of Medicine for DOODY'S PUBLISHING