Drug Metabolism and Transport: Molecular Methods and Mechanisms by Lawrence H. LashDrug Metabolism and Transport: Molecular Methods and Mechanisms by Lawrence H. Lash

Drug Metabolism and Transport: Molecular Methods and Mechanisms

EditorLawrence H. Lash

Paperback | November 9, 2010

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A compendium of proven experimental approaches and strategies for studying the bioactivation, detoxification, tissue distribution, and elimination of xenobiotics in the metabolism and/or transport of various chemicals. The authors address several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxygenases, glutathione, S-transferase, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present novel approaches to the study of: signaling pathways in the regulation of drug metabolism enzymes, how the modulation of thiols and other low molecular-weight cofactors can alter drug metabolism, and how modulation of drug metabolism pathways can influence antiviral therapy.
Title:Drug Metabolism and Transport: Molecular Methods and MechanismsFormat:PaperbackDimensions:398 pages, 9.02 × 5.98 × 0.03 inPublished:November 9, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617374946

ISBN - 13:9781617374944

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Table of Contents

Renal Cytochrome P450s and Flavin-Containing Monooxygenases: Potential Roles in Metabolism and Toxicity of 1,3-Butadiene, Trichloroethylene, and TetrachloroethyleneAdnan A. ElfarraExperimental Approaches for the Study of Cytochrome P450 Gene RegulationHollie I. Swanson, Susan D. Kraner, Soma S. Ray, Martin Hoagland, Earl D. Thompson, Xinyu Zheng, and Yanan TianInsulin and Growth Factor Signaling: Effects on Drug-Metabolizing EnzymesSang K. Kim, Kimberley J. Woodcroft, and Raymond F. NovakCatalytic Function and Expression of Glutathione Transferase ZetaPhilip G. Board, M. W. Anders, and Anneke C. BlackburnGlucuronidation of Fatty Acids and Prostaglandins by Human UDP-GlucuronosyltransferasesAnna Radominska-Pandya, Joanna M. Little, and Arthur BullTranscriptional Regulation of UDP- GlucuronosyltransferasesAnna Radominska-Pandya, Peter I. Mackenzie, and Wen XiePhenotypic and Genotypic Characterization of N-AcetylationCraig K. Svensson and David W. HeinMethods and Approaches to Study Metabolism and Toxicity of AcetaminophenSam A. BruschiModulation of Drug Metabolism and Antiviral TherapiesBernhard H. LauterburgModulation of Thiols and Other Low-Molecular-Weight Cofactors: Effects on Drug Metabolism and Disease SusceptibilityCharles V. SmithMultidrug Resistance Proteins and Hepatic Transport of Endo- and XenobioticsPhillip M. Gerk and Mary VoreStructural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate CarrierWei Cao and Larry H. MatherlyGlutathione Transport in the Kidneys: Experimental Models, Mechanisms, and MethodsLawrence H. LashHuman Cytosolic Sulfotransferases: Properties, Physiological Functions, and ToxicologyCharles N. FalanyIndex

Editorial Reviews

"With the diverse subject matter and the wealth of information on techniques and research strategies there is likely to be something in this book to interest those from PhD students to more experienced researchers." -Newsletter of the British Toxicological Society