Endocrine Disruption And Human Health

Hardcover | March 25, 2015

byPhilippa D. DarbreEditorPhilippa D. Darbre

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Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

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Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects o...

Dr Philippa Darbre is Associate Professor in Oncology in the School of Biological Sciences at the University of Reading in the UK. She is an academic scientist who has been carrying out research into estrogen action in breast cancer for over 30 years and has been investigating the role of estrogen-mimicking chemicals since before the t...
Format:HardcoverDimensions:390 pages, 9.41 × 7.24 × 0.98 inPublished:March 25, 2015Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128011394

ISBN - 13:9780128011393

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Table of Contents

SECTION 1 OVERVIEW and SCOPE 1. What is endocrine disruption? 2. Which chemicals are endocrine disruptors?SECTION 2 MECHANISMS and ASSAY SYSTEMS 3. Environmental oestrogens: disrupters of oestrogen action 4. Disrupters of androgen action 5. Assay systems for studying endocrine disruption 6. Non-monotonic responses in endocrine disruption 7. Endocrine disrupters as modifiers of endogenous hormone synthesisSECTION 3 CONCERNS FOR HUMAN HEALTH 8. Endocrine disruption and female reproductive health 9. Endocrine disruption and breast cancer 10. Endocrine disruption and male reproductive health 11. Endocrine disruption and prostate cancer 12. Endocrine disruption and thyroid disease 13. Endocrine disruption of adrenal function 14. Endocrine disruption of developmental pathways and children's health 15. Endocrine disruption of immune function 16. Endocrine disruption and obesity, metabolic syndrome and type 2 diabetes 17. Endocrine disruption and cardiovascular disease 18. Transgenerational effects of endocrine disruption 19. Regulatory considerations