Enzyme Nanocarriers by Daniela CardinaleEnzyme Nanocarriers by Daniela Cardinale

Enzyme Nanocarriers

EditorDaniela Cardinale, Thierry Michon

Hardcover | September 10, 2015

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Enzyme immobilization on solid supports has been considered for a long time as an attractive solution to perform sophisticated organic synthesis, which is required in the preparation of fine pharmaceutical chemicals. But in the late 1990s, the tremendous progress in molecular biology fundamentals opened up the possibility of feeding a toolbox for building new bioinspired nanotechnologies. Among them is the goal of repositioning biocatalysts in environments mimicking their genuine working place'the cell.

The research presented in this book was selected among the most impressive achievements in the fields of enzyme bioconjugation and bioinspired nanosupports. It opens up potential applications in nanocatalysis and for lab-on-a-chip and biosensor devices, drug delivery vectors, and nanometrology. Most of the supports described pertain to soft materials (cells, virus, polymers, DNA) and most of the examples benefit from the amazing properties of proteins and DNA to self-assemble, according to the "bottom-up law," a specific feature of all living systems. The enzyme nanocarriers also have the potential to be grafted on solid supports through "top-down" technologies, spanning orders of magnitude from the nano- to the mesoscale and above. The book is a rich source of inspiration for researchers seeking to build smart materials requiring nanoscale positional control of functional proteins on various carriers.

Daniela Cardinaleis postdoctoral researcher, since 2010, at the French National Institute of Agricultural Research (INRA), France, where she has integrated Dr. Thierry Michon's team and investigated different strategies aiming to a positional control of enzymes on viral particles. She was awarded a PhD in biochemistry at the University...
Title:Enzyme NanocarriersFormat:HardcoverDimensions:266 pages, 9 × 6.1 × 0.9 inPublished:September 10, 2015Publisher:Taylor and FrancisLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:9814613428

ISBN - 13:9789814613422

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Table of Contents

Virus diversity to explore various kinds of enzyme nanocarriers;Jane Besong-Ndika, Jocelyne Walter, and Kristiina M'nen

Strategies for virus coupling of enzymes;Daniela Cardinale, No'e Carette, and Thierry Michon

Viruses as model nanoreactors to study enzyme kinetics;W. Frederik Rurup, Melissa S. T. Koay and Jeroen J. L. M. Cornelissen

Nanoscale compartmentalization techniques in cascade catalysis;Jorgen S. Willemsen, Floris P. J. T. Rutjes, and Jan C. M. van Hest

Nanocarriers for Therapeutic Enzymes;Melissa D. Howard, Elizabeth D. Hood, and Vladimir R. Muzykantov

DNA-origamis as protein nanocarriers;Juan Elezgara, Jean-Pierre Aim'and Jean-Michel Arbona

Nanopatterning for nanobiotechnologies: emerging methods based on soft-lithography and directed assembly;Aline Cerf , Christophe Thibault , Emmanuelle Tr'siol, and Christophe Vieu

Editorial Reviews

"A timely and well-presented treatise on the evolving use of biological assemblies for nanocarriers of enzymes with potential applications in catalysis and the delivery of enzyme therapeutics. In seven chapters the expert authors describe the utility of viruses, polymersomes and DNA origamis. The book will be of great value not only to the specialist but also to others with a general interest in the broader field of bionanotechnology."¿ Prof. David J. Evans, University of Hull, UK