Enzyme-Prodrug Strategies For Cancer Therapy

Hardcover | January 31, 1999

EditorRoger G. Melton, Richard J. Knox

not yet rated|write a review
Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. Antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue. ADEPT offers a novel field of opportunities in the therapy of systemic cancer and may be a major advance for the treatment of solid tumours. This book is the first to describe ADEPT in detail. Each chapter reviews an aspect of the immunology, enzymology, biochemistry, chemistry, and cancer chemotherapy which have been integrated into the ADEPT concept. An additional chapter describes the related approach of gene-directed enzyme prodrug therapy (GDEPT). This latter approach is still in its infancy but ADEPT has entered the clinic. The initial clinical studies with ADEPT are included and discussed in detail.

Pricing and Purchase Info

$297.95

In stock online
Ships free on orders over $25

From the Publisher

Antibody-directed enzyme prodrug therapy (ADEPT) directly addresses the major problem in cancer chemotherapy-its lack of selectivity. Antibody delivery combined with the amplification provided by the enzymatic activation of prodrugs enables selection to be made between tumour and normal tissue. ADEPT offers a novel field of opport...

Format:HardcoverDimensions:270 pages, 9.25 × 6.1 × 0 inPublished:January 31, 1999Publisher:Springer USLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0306458950

ISBN - 13:9780306458958

Look for similar items by category:

Customer Reviews of Enzyme-Prodrug Strategies For Cancer Therapy

Reviews

Extra Content

Table of Contents

Introduction; R.J. Knox, R.G. Melton. Prodrugs in Cancer Chemotherapy; T. Connors. Factors Influencing Tumor-Selective Localization of Antibody Conjugates; M.A. Sims, R.G. Melton. Enzymes and Prodrugs Used for ADEPT; R.J. Knox. The Design and Synthesis of Prodrugs for Antibody-Directed Enzyme Prodrug Therapy (ADEPT); P.J. Burke. Preparation and Purification of Antibody-Enzyme Conjugates for Therapeutic Applications; R.G. Melton. Phage Technology for Producing Antibody-Enzyme Fusion Proteins; K.A. Chester, et al. Early Clinical Studies with ADEPT; K.D. Bagshawe, M. Napier. Gene-Directed Enzyme Prodrug Therapy (GDEPT) of Cancer; R.J. Knox. Appendix: Enzymes and Prodrugs Proposed for Cancer Therapy. References. Index.