Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact by J. David SweattEpigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact by J. David Sweatt

Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical Impact

byJ. David Sweatt, J. David Sweatt, Michael J. Meaney...

Other | December 31, 2012

Pricing and Purchase Info

$132.79 online 
$166.00 list price save 20%
Earn 664 plum® points

Prices and offers may vary in store


In stock online

Ships free on orders over $25

Not available in stores


Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system.

Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions.

Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia.

  • BMA Medical Book Awards 2014 - Highly Commended,  Neurology, British Medical Association
  • BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association
  • 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers
  • Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between
  • Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists
  • Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics
Schahram Akbarian studied medicine at the Freie Universitaet Berlin, Germany. He is a board certified psychiatrist and molecular neuroscientist who trained at the Massachusetts General Hospital in Boston, the Whitehead Institute for Biomedical Research in Cambridge and the University of California at Irvine. In 2002, he joined the Univ...
Title:Epigenetic Regulation in the Nervous System: Basic Mechanisms and Clinical ImpactFormat:OtherDimensions:374 pages, 1 × 1 × 1 inPublished:December 31, 2012Publisher:Elsevier ScienceLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123944058

ISBN - 13:9780123944054


Table of Contents

1. An Overview of the Molecular Basis of EpigeneticsJ. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian

2. Histone modifications in the nervous system and neuropsychiatric disordersMorgan Bridi and Edwin "Ted" Abel

3. Active DNA Demethylation and 5-HydroxymethylcytosineJunjie U. Guo, Guo-li Ming and Hongjun Song

4. Maternal BehaviorTie Yuan Zhang, Christian Caldji, Josie C. Diorio, Sabine Dhir, Gustavo Turecki, and Michael J. Meaney

5. Epigenetic Mechanisms in Learning and MemoryJeremy J. Day and J. David Sweatt

6. Drug Addiction and RewardAlfred J. Robison, Jian Feng, and Eric J. Nestler

7. The Mind and its Nucleosomes - Chromatin (dys)regulation in Major Psychiatric DiseaseRahul Bharadwaj, Cyril J. Peter, and Schahram Akbarian

8. HDAC inhibitors as novel therapeutics in Aging, and Alzheimer's diseaseAlexi Nott, Daniel M. Fass, Stephen J. Haggarty, and Li-Huei Tsai

9. Cell Differentiation in the CNS, Neuronal Fate Determination, and DevelopmentYi Eve Sun

10. Imprinting in the CNS and Neurodevelopmental DisordersWeston T. Powell and Janine LaSalle

11. Neuronal Genomic and Epigenetic DiversityMichael J. McConnell and Fred H. Gage

12. Adult NeurogenesisJenny Hsieh, Hongjun Song

13. Transgenerational Inheritance in MammalsIsabelle M. Mansuy, Rahia Mashoodh and Francis A. Champagne

14. Open Questions and Future Approaches in NeuroepigeneticsJ. David Sweatt, Michael J. Meaney, Eric J. Nestler, and Schahram Akbarian