Epigenetics In Psychiatry

Paperback | October 30, 2017

byJacob PeedicayilEditorDennis R. Grayson, Dimitri Avramopoulos

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Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

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Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter co...

Jacob Peedicayil has published 46 review papers, 3 book chapters and is engaged in various editorial review boards and journal positions. His interests include theoretical research in psychiatric epigenetics and muscle-based pharmacology.Dr. Grayson has been interested in mechanisms associated with gene expression for over 20 years. He...

other books by Jacob Peedicayil

Neuropsychiatric Disorders and Epigenetics
Neuropsychiatric Disorders and Epigenetics

Kobo ebook|Nov 15 2016

$102.49 online$133.00list price(save 22%)
Format:PaperbackDimensions:664 pages, 8.75 × 6.35 × 0.68 inPublished:October 30, 2017Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0128101083

ISBN - 13:9780128101087

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Table of Contents

  1. Introduction
  2. Outline of Epigenetics
  3. History of Epigenetics in Psychiatry
  4. Role of Epigenetics in the Neural Stem Cell and Neuron
  5. Role of Epigenetics in the Brain
  6. Epigenetic Epidemiology of Psychiatric Disorders
  7. Laboratory Techniques in Psychiatric Epigenetics
  8. Laboratory Models in Psychiatric Epigenetics
  9. DNA Methylation and Histone Changes in Schizophrenia
  10. Non-Coding RNAs and Major Psychosis
  11. Epigenetics and Bipolar Disorder
  12. Epigenetics and Major Depressive Disorder
  13. Epigenetics and Suicide
  14. Epigenetics of Anxiety Disorder and Post-Traumatic Stress Disorder
  15. Epigenetics and Cognitive Disorders
  16. Epigenetics and Mental Retardation
  17. Epigenetics of Pervasive Developmental Disorders and ADHD
  18. Epigenetics and Drug Addiction
  19. Epigenetic Effects of Currently-Used Psychotropic Drugs
  20. Drugs Affecting DNA Methylation in Psychiatric Disorders;
  21. Histone Deacetylase Inhibitors and Psychiatric Disorders
  22. The Social Environment and Epigenetics in Psychiatry
  23. Nutritional Influences on Epigenetics in Psychiatry
  24. Transgenerational Epigenetics and Psychiatric Disorders