Essential Concepts in Toxicogenomics by Donna L. MendrickEssential Concepts in Toxicogenomics by Donna L. Mendrick

Essential Concepts in Toxicogenomics

EditorDonna L. Mendrick, William B. Mattes

Paperback | November 19, 2010

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The field of toxicogenomics has been growing quickly, yet with rapid growth comes the need to periodically reflect on the nature of the field. Essential Concepts in Toxicogenomics collects reviews, opinion pieces and case studies from the leading experts in this dynamic field with a focus on its application to pharmaceuticals. Topics covered include issues that affect the quality of toxicogenomics experiments, statistical approaches to their data analysis, the use of such data to build toxicogenomic models, and the utilization of genomics to identify biomarkers within the preclinical and clinical arenas. Although not in the standard Methods in Molecular BiologyT series format, this volume retains the practicality and usefulness of the highly successful series.Informative and cutting-edge, Essential Concepts in Toxicogenomics is an ideal resource for pharmaceutical companies, chemical manufacturers, toxicologists, and all who must keep up-to-date on progress in this vital and important field.
Title:Essential Concepts in ToxicogenomicsFormat:PaperbackDimensions:288 pagesPublished:November 19, 2010Publisher:Humana PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1617376884

ISBN - 13:9781617376887

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Table of Contents

Toxicogenomics and Classical Toxicology: How to Improve Prediction and Mechanistic Understanding of Human ToxicityDonna L. MendrickUse of Traditional Endpoints and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic ToxicologyWayne R. Buck, Jeffrey F. Waring, Eric A. Blomme. Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications Karol L. Thompson and Joseph HackettRole of Statistics in ToxicogenomicsMichael ElashoffPredictive Toxicogenomics in Preclinical DiscoveryScott A. Barros and Rory B. MartinIn Vivo Predictive ToxicogenomicsMark W PorterBioinformatics: Databasing and Gene AnnotationLyle D. Burgoon and Timothy R. ZacharewskiMicroarray Probe Mapping and Annotation in Cross-Species Comparative ToxicogenomicsJohn N Calley, William B Mattes, and Timothy RyanToxicogenomics in Biomarker DiscoveryMarc F. DeCristofaro and Kellye K. DanielsFrom Pharmacogenomics to Translational BiomarkersDonna L. MendrickPublic Consortium Efforts in ToxicogenomicsWilliam B. MattesApplications of Toxicogenomics to Nonclinical Drug Development - Regulatory Science ConsiderationsFrank D. Sistare and Joseph J. DeGeorge

Editorial Reviews

From the reviews:"'Essential Concepts in Toxicogenomics' is a collections of reviews, opinion pieces and case studies written by experts in the field. . gives good coverage of whole field of toxicogenomics. . If you want to get up to steam with this area then . it is certainly worth reading this book." (James Sidaway, BTS Newsletter, Winter, 2008)