Essentials of Genomic and Personalized Medicine

Other | October 2, 2009

byGeoffrey S. Ginsburg, Geoffrey S. Ginsburg, Huntington F Willard

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Derived from the comprehensive two-volume set,Genomic and Personalized Medicinealso edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications,Essentials of Genomic and Personalized Medicinewill be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine.

* Full color throughout
* Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field
* Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice
* Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

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From the Publisher

Derived from the comprehensive two-volume set,Genomic and Personalized Medicinealso edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of...

Huntington Willard is President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. Prior to his appointment at the MBL, Willard was on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to...

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Format:OtherDimensions:850 pages, 1 × 1 × 1 inPublished:October 2, 2009Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080958117

ISBN - 13:9780080958118

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Table of Contents

1 Introduction

Section 1 - Basics2 Organization, Variation and Expression of the Human Genome 3 DNA Sequencing for the Detection of Human Genome Variation 4 Genome-Wide Association Studies and Genotyping Technologies 5 Copy Number Variation and Human Health 6 DNA Methylation Analysis: Providing New Insight into Human Disease 7 DNA Microarrays in Biological Diversity and Patient Care 8 Proteomics: The Deciphering of the Functional Genome 9 Comprehensive Metabolic Analysis for Understanding Disease

Section 2 - Informatics10 Bioinformatic and Computational Analysis for Genomic Medicine 11 Systems Biology and Systems Medicine 12 Electronic Medical Records in Genomic Medicine Practice and Research 13 Health Information Retrieval for Consumers

Section 3 - Translational14 Genomics to Health: Challenges and Opportunities 15 Pharmacogenetics and Pharmacogenomics 16 Clinical Implementation of Translational Genomics 17 The Role of Genomics in Enabling Prospective Health 18 From Sequence to Genomic Medicine: Genome Policy Considerations 19 Federal Regulation of Genomic Medicine 20 Economic Issues and Genomic Medicine 21 Public Health Genomics

Section 4 - Clinical (Cardiology)22 Hypertension 23 Lipiprotein Disorders 24 Myocardial Infarction 25 Acute Coronary Syndromes 26 Heart Failure in the Era of Genomic Medicine 27 Genomic Assessment of Cardiac Transplant Rejection 28 Hypertrophic Cardiomyopathy 29 Arrhythmias 30 Genetics and Genomics in the Management of Hemostasis & Thrombosis 31 Genomics of Congenital Heart Disease

Section 5 - Clinical (Oncology)32 Genomics in the Management of Lymphomas 33 Genomics in Leukemias 34 Lung Cancer 35 Genomics in the Diagnosis and Management of Breast Cancer 36 Colorectal Cancer 37 Prostate Cancer 38 Genomic Assessment of Ovarian Cancer 39 Genomic Evaluation of Pancreatic Neoplasms 40 Genomic Evaluation of Head and Neck Cancer 41 Genomic Medicine, Evaluation of Brain Tumors and Gliomas 42 Diagnostic - Therapeutic Combinations in the Targeted Therapies for Treatment of Cancer

Section 6 - Clinical (Inflammatory Disease)43 Genomics in the Evaluation and Management of Rheumatoid Arthritis 44 "Omics" in the Genomic Evaluation of Multiple Sclerosis 45 Genomic Assessment of Inflammatory Bowel Disease 46 Asthma Genomics 47 Genomic Aspects in the Evaluation and Management of Chronic Obstructive Pulmonary Disease 48 Genetics and Genomics of Interstitial Lung Disease 49 Peptic Ulcer Disease

Section 7 - Clinical (Metabolic Disease)50 Genomics in Pathogenesis of Cirrhosis 51 Genomic Medicine and Obesity 52 Diabetes

Section 8 - Clinical (Neurological Disease)53 Genetics and Genomics of Dementia 54 Genetics and Genomics of Parkinson's Disease 55 Genomic Considerations in Opthamology 56 Genomics in the Diagnosis and Management of Depression

Section 9 - Clinical (Infectious Disease)57 "Genomic Approaches to the Host Response to Pathogens" 58 Host Genomics and Bacterial Infections 60 Diagnosis, Genomics, and the Management of Hepatitis