Eukaryotic Cell Function and Growth: Regulation by Intracellular Cyclic Nucleotides by Jacques DumontEukaryotic Cell Function and Growth: Regulation by Intracellular Cyclic Nucleotides by Jacques Dumont

Eukaryotic Cell Function and Growth: Regulation by Intracellular Cyclic Nucleotides

byJacques Dumont

Paperback | May 22, 2013

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The day it rained in Wepion ..... . The NATO Course on Regulation of Function and Growth of Eukaryo­ tic Cells by Intracellular Cyclic Nucleotides was organized in Wepion (Belgium) from September 23 to October 1, 1974, by L. Birn­ baumer (Chicago), B.L. Brown (London), R.W. Butcher (Worcester), J.E. Dumont (Brussels), M. Paiva (Brussels) and G. Van den Berghe (Louvain), under the benevolent and most efficient aegis of Dr. T. Kester (NATO, Brussels). The formula of the Course was inspired by the Gordon Con­ ference with its combination of a pleasant, friendly and easygoing atmosphere together with a solid and critical scientific diet offered in the morning and evening, the afternoon being free. For these reasons, the meeting was located in a pleasant motel in beautiful surroundings by the side of the Meuse river, in the country, but close to the town of Narnur. Everything, absolutely everything, from swimming to tennis, to horse riding,was available to make the afternoons agreeable and to facilitate social contacts.
Title:Eukaryotic Cell Function and Growth: Regulation by Intracellular Cyclic NucleotidesFormat:PaperbackDimensions:838 pagesPublished:May 22, 2013Publisher:Springer-Verlag/Sci-Tech/TradeLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:1461343240

ISBN - 13:9781461343240

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Table of Contents

Cell Fractionation by Centrifugation Methods.- - Introduction.- - Homogenization.- - Fractionation methods.- - Analysis of the fractions and interpretation of the results.- - Conclusion.- - References.- Binding of Ligands to Receptors: Theory.- - Introduction.- - Experimental approach to the hormone-receptor interaction.- - Molecular models of receptors.- - Graphical representations of saturation experiments.- - Methodologic errors and graphical representations.- - Conclusion.- - References.- On the Modes of Regulation of Intracellular Cyclic AMP: Desensitization of Adenylyl Cyclases to Hormonal Stimulation and Compartmentalization of Cyclic AMP.- - Introduction.- - Regulation of cyclic AMP levels by desensitization of adenylyl cyclase to hormonal stimulation.- - Regulation of cyclic AMP levels by compartmentalization of cyclic AMP.- - Nomenclature used.- - Abbreviations used.- - References.- The Interaction of Glucagon with Isolated Plasma Membranes of Rat Livers: The Relevancy of Measuring Binding Sites.- - Introduction.- - Transfer of hormonal message.- - Iodination of hormones.- - Measurement of binding.- - Relation between binding and adenylate cyclase.- - Effect of guanyl nucleotides on binding.- - How reliable is the measurement of binding as an indication of the first step in translation of the hormonal message ?.- - Degradation of glucagon by its target organ.- - The functional meaning of the receptor site.- - Summary.- - References.- Hormone Binding To Receptors: Vasopressin.- - Introduction.- - Methodological and technical considerations.- - Binding of lysine-vasopressin to pig kidney plasma membranes.- - Correlations between hormone binding and adenylate cyclase activation.- - References.- Effects of Choleragen and Fluoride on Adenylate Cyclase.- - Activation of adenylate cyclase by choleragen.- - Effects of fluoride on adenylate cyclase.- - References.- Stimulation of Adenylate Cyclase in the Thyroid.- - Introduction.- - TSH stimulation of adenylate cyclase in the thyroid.- - Immunoglobulin stimulation of adenylate cyclase in the thyroid.- - Prostaglandin stimulation of adenylate cyclase in the thyroid.- - Catecholamine stimulation of adenylate cyclase in the thyroid.- - Stimulation of adenylate cyclase in the thyroid by fluoride, bacterial products and biogenic amines.- - Conclusion.- - References.- Guanylate Cyclase.- - Introduction.- - Methods of assay.- - Distribution.- - General properties.- - Similarities in some properties of adenylate and guanylate cyclases.- - Effects of hormones and neurotransmitters on guanylate cyclase activity in cell free systems.- - References.- Regulation of Cyclic AMP Phosphodiesterase Activity.- - Effect of insulin on fat cell phosphodiesterase activity.- - Effects of intracellular cyclic AMP concentration on fat cell phosphodiesterase activity.- - Effects of prolonged elevation of cyclic AMP on phosphodiesterase activity.- - Effects of steroid hormones on phosphodiesterase activity.- - References.- Theoretical Simulation of the cAMP System.- - Introduction.- - Protein kinase and cyclic AMP.- - Consequences of the intracellular distribution of phosphodiesterases.- - Conclusion.- - References.- Control of Metabolic Processes by cAMP-Dependent Protein Phosphorylation.- - Introduction.- - Hormonal effects on cAMP-dependent protein kinases in intact tissues.- - Multiple forms of cAMP-dependent protein kinase.- - Effects of MgATP.- - Translocation.- - Phosphoprotein phosphatases.- - References.- Cyclic AMP and Cyclic GMP Binding in Tissues.- - Introduction.- - Characteristics of the cyclic AMP binding system.- - Cyclic GMP binding system.- - Hormonal regulation - intracellular titration of cyclic AMP bound to receptor proteins in rat diaphragm.- - Conclusions.- - References.- The Assay of Cyclic AMP in Biological Material.- - Introduction.- - Method of cyclic AMP analysis.- - Assay of cyclic AMP in biological samples.- - Summary.- - References.- Determination of Cyclic GMP in Biological Material.- - Introduction.- - Determination of cyclic GMP.- - Application to biological material.- - References.- Methods for the Study of Cyclic AMP Metabolism in Intact Cells.- - Introduction.- - Methods.- - Results.- - Conclusions.- - References.- The Actions of Nucleotides on Adenylyl Cyclase Systems.- - Introduction and basic observations.- - Effect of nucleotides on the behavior of the catalytic unit(s).- - Effect of nucleotides on the behavior of the hormone receptor.- - Effects of nucleotides on the coupling (or transduction) process and multiplicity of sites of nucleotide interaction.- - Nomenclature used.- - Abbreviations.- - References.- Cyclic AMP Metabolism of Some Fibroblastic and Epithelial Cells in Vitro.- - Introduction.- - Methods.- - Lack of correlation between intact cell studies and cell-free enzyme studies.- - Release of cyclic AMP from cells.- - Comments.- - References.- Metabolism of Cyclic GMP in Vascular Smooth Muscle, Leukocytes, and Lung.- - Vascular smooth muscle.- - Leukocytes.- - Lung.- - References.- Cyclic Nucleotide Analogues.- - Introduction.- - Synthetic principles.- - Structure of modifications.- - Structure-activity-relations.- - Cyclic analogues - Useful therapeutical agents?.- - References.- Microtubule Morphology.- - Introduction.- - Substructure of the microtubules.- - Associated structures: the centrioles and the cilia.- - Agents acting on microtubules.- - Morphological evidences of microtubular functions.- - References.- Cyclic AMP and Microtubules.- - Introduction.- - Subunits and structure of tubulin.- - Binding sites of tubulin.- - Purification and polymerization of tubulin.- - ATPases and nucleotide transphosphorylase activities "associated" with tubulin.- - Cyclic AMP and tubulin.- - In vitro and in vivo phosphorylation reactions catalyzed by "associated" protein kinase.- - Polymerization of tubulin and phosphorylation reactions.- - Conclusions.- - References.- Prostaglandins and Cyclic Nucleotides.- - Introduction.- - Effects of exogenous prostaglandins on adenylate cyclase in various tissues.- - Biological significance of cyclic AMP formation induced by prostaglandins in target organs of hormones.- - Prostaglandins as connecting factors between cyclic AMP and cyclic GMP systems : a tentative explanation.- - Conclusions.- - References.- Re-Examination of the Role of Cyclic AMP in the Actions of Glucagon and Epinephrine.- - Introduction.- - Cyclic AMP as the mediator of glucagon action in liver.- - Studies on the role of cyclic AMP in the hepatic actions of catecholamines using the isolated perfused rat liver.- - Studies on the role of cyclic AMP in catecholamine action using isolated liver parenchymal cells.- - A dual mechanism for catecholamine actions in liver.- - References.- The Role of Cyclic AMP in the Regulation of Glycogen Metabolism.- - Introduction.- - The pathway of glycogen metabolism.- - The two forms of glycogen phosphorylase and synthetase.- - The regulation of the interconversion of the two forms of glycogen phosphorylase and synthetase.- - References.- Cyclic AMP and Pyruvate Dehydrogenase.- - Introduction.- - Effects of hormones on adipose tissue PDH.- - Failure in inverse correlation of lipolysis rate with PDH activity of adipose tissue.- - Attempts to demonstrate direct effects of cyclic AMP on the PDH comple.- - Possible roles for cyclic AMP in pyruvate dehydrogenase regulation.- - References.- Cyclic AMP and Protein Synthesis.- - Introduction.- - Suppression or enzyme induction.- - References.- Cyclic AMP and the Control of Lypolysis in Fat Cells of the Rat.- - Introduction.- - Correlation of cyclic AMP levels and lipolysis.- - Insulin action : adenylate cyclase or phosphodiesterase?.- - References.- Studies on the Permissive Effect of the Thyroid on Fat Cells.- - References.- Cyclic Nucleotides, Calcium and Ion Transport.- - Introduction.- - The mechanism of fluid secretion.- - The role of cyclic AMP and calcium.- - Interactions between cyclic AMP and calcium.- - Comparison with mammalian systems.- - Conclusion.- - References.- Insulin Secretion - The Role and Mode of Action of Cyclic AMP.- - Introduction.- - The process of insulin secretion.- - Components of the cyclic AMP system in islets of Langerhans.- - Interaction of secretagogues with components of the B cell cyclic AMP system.- - The role of cyclic AMP in the regulation of insulin secretion.- - Mode of action of cyclic AMP in regulating insulin secretion.- - Conclusions.- - References.- Effects of Cyclic AMP on B-Cell Function.- - Introduction.- - The insulinotropic action of cAMP.- - The effects of cAMP on insulin glucose metabolism.- - The effect of cAMP on calcium handling by isolated islets.- - The effects of cAMP on proinsulin biosynthesis.- - The effect of cAMP on the B-cell microtubular microfilamentous system.- - Conclusions.- - Rferences.- Role of Cyclic Nucleotides in the Anterior Pituitary Gland.- - Introduction.- - Mechanism of action of hypothalamic regulatory hormones.- - Target gland hormone feedback.- - Summary.- - References.- Mechanism of LH and FSH Action on the Testis.- - Introduction.- - Preparation of testis tissues and cells.- - Experimental models for the mechanisms of LH and FSH action.- - LH and FSH receptors.- - Cyclic AMP and testosterone production.- - Protein kinase.- - Protein and RNA synthesis.- - Summary and conclusions.- - References.- Possible Roles of Cyclic Nucleotides in the Regulation of Smooth Muscle Tonus.- - Introduction.- - Cyclic AMP.- - Cyclic GMP.- - Concluding remarks.- - References.- The Regulation of Thyroid Cell Metabolism.- - Introduction.- - Thyroid cellular physiology.- - Methodology of the investigation of thyroid cellular metabolism.- - Framework of the investigation of the regulation of thyroid metabolism.- - Model of thyroid cell regulation.- - The cyclic AMP system.- - Regulation by iodide of the cyclic 3',5'-AMP system.- - Role of calcium.- - The cyclic 3',5'-GMP system.- - Conclusion.- - References.- Behavior of Cultured Fibroblasts, the Cell Surface and Cyclic AMP.- - Behavior of fibroblasts in culture.- - The cell surface and the control of growth.- - Cell behavior and cyclic AMP.- - Summary.- - References.- Chromatin Structure and the Role of Histone Phosphorylation in the Cell Cycle.- - References.- Cyclic Nucleotides and Cell Adhesion.- - Introduction.- - Methods.- - Results.- - Discussion.- - References.- Cyclic AMP and Cancer.- - Introduction.- - Effect of cyclic AMP analogues on malignant fibroblasts.- - Cyclic AMP levels in transformed cells.- - Cyclic AMP during transformation.- - Conclusion.- - References.- Cyclic Nucleotides and Cell Growth.- - Introduction.- - The pleiotypic control.- - The Yin Yang or dualism hypothesis of biological control through cyclic AMP and cyclic GMP.- - Experimental evidence in different cell types.- - Conclusion.- - References.- Cyclic AMP and Myoblast Differentiation.- - Introduction.- - Results and discussion.- - References.- Diseases Involving Cyclic AMP.- - Introduction.- - The cyclic nucleotides in plasma and urine.- - Disorders with decreased formation of cAMP.- - Disorders with increased production of cAMP.- - References.