Eukaryotic DNA Replication

Paperback | April 30, 1999

EditorJ. Julian Blow

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A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge ofinterest in the subject.

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A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge ofinterest in the subject.

J. Julian Blow is at ICRF Clare Hall Labs, Blanche Lane, South Mimms.

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Format:PaperbackDimensions:252 pages, 9.69 × 7.44 × 0.59 inPublished:April 30, 1999Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0199635854

ISBN - 13:9780199635856

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Table of Contents

1. Enzymology of the replication fork2. SV40 DNA replication3. The initiation of DNA replication in the year Saccharomyces cerevisiae4. Replication origins in metazoan chromosomes5. Role of nuclear structure in DNA replication6. Chromosome replication in Xenopus egg extracts7. Cell cycle control of DNA replication in Saccharomyces cerevisiae8. Regulation of S phase in the fission yeast Schizosaccharomyces pombe

Editorial Reviews

"This volume is largely successful in capturing the key issues of the eukaryotic DNA replication field, including enzymology of the replication fork, the structure of replication origins, and the regulation of DNA replication, and in summarizing recent progress. An attractive feature of the volumeis the juxtaposition of chapters that highlight contributions from the genetically tractable budding and fission yeasts with chapters that highlight contributions of the more biochemical and cell biological approaches necessary in Xenopus and mammalian cells." --Science"Eight thoughtful reviews with clear figures and diagrams written by experts in the field. Together, these reviews provide a framework for thinking about cellular DNA replication in which students, teachers, and researchers should be able to integrate developments in this fast-moving field."--Science"Provides a current survey of research. . . .A generally well-written, heavily referenced, and well illustrated work for upper-division undergraduates, graduate students, and faculty."--Choice