Eukaryotic Transcription Factors

Other | November 1, 2003

byLatchman, David S., David S. Latchman

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Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.

This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality.

* Major families of eukaryotic transcription factors described
* Mechanisms of gene activation and repression analysed
* Structure-function relationships indicated
* Interaction between transcription factors and chromatin structure described
* Roles in inducible and cell type-specific gene expression
* Roles in development, differentiation and human diseases including cancer
* Methods of study in vitro and in vivo

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From the Publisher

Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcripti...

Format:OtherDimensions:384 pages, 1 × 1 × 1 inPublished:November 1, 2003Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080531261

ISBN - 13:9780080531267

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Extra Content

Table of Contents

List of Tables
DNA sequences, transcription factors and chromatin structure
The importance of transcription
Chromatin structure and its remodelling
Chromatin structure and gene regulation
Chromatin remodelling factors
Histone acetylation
DNA sequence elements
The gene promoter
Sequences involved in the basic process of transcription
Sequences involved in regulated transcription
Sequences which act at a distance
Negatively acting DNA sequences
Interaction between factors bound at various sites
Conclusions
References
Methods for studying transcription factors
Introduction
Methods for studying DNA-protein interactions
DNA mobility shift assay
DNaseI footprinting assay
Methylation interference assay
In vivo Footprinting assay
Methods for purifying and/or cloning transcription factors
Protein purification
Gene cloning
Use of cloned genes
Domain mapping of transcription factors
Determining the DNA binding specificity of an uncharacterised factor
Identification of target genes for transcription factors
Conclusions
References