Evolution in Health and Disease

Paperback | November 26, 2007

EditorStephen C. Stearns, Jacob C. Koella

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In this fully revised and updated edition, the editors have integrated a completely new set of contributions from the leading researchers in the field to describe the latest research in evolutionary medicine, providing a fresh summary of this rapidly expanding field 10 years after itspredecessor was first compiled. It continues to adopt a broad approach to the subject, drawing on medically relevant research from evolutionary genetics, human behavioural ecology, evolutionary microbiology (especially experimental evolution of virulence and resistance), the evolution of aging anddegenerative disease, and other aspects of biology or medicine where evolutionary approaches make important contributions.iEvolution in Health and Disease/i describes how evolutionary thinking gives valuable insights and fresh perspectives into human health and disease, establishing evolutionary biology as an essential complementary science for medicine. Integrating evolutionary thought into medical research andpractice helps to explain the origins of many medical conditions, including diabetes, obesity, cardiovascular disease, asthma, allergies, other autoimmune diseases, and aging. It also provides life-saving insights into the evolutionary responses of pathogens to antibiotics, vaccinations, and otherhuman interventions. Why do we grow old? How can we stay healthy as we age? The book discusses these and many other fascinating questions, as well as suggesting exciting possibilities for future treatment and research.This research level text is suitable for graduate level students and researchers in the fields of evolutionary (Darwinian) medicine, evolutionary biology, anthropology, developmental biology and genetics. It will also be of relevance and use to medical researchers and doctors.

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In this fully revised and updated edition, the editors have integrated a completely new set of contributions from the leading researchers in the field to describe the latest research in evolutionary medicine, providing a fresh summary of this rapidly expanding field 10 years after itspredecessor was first compiled. It continues to adop...

iProfessor Stearns/i specializes in life history evolution, which links the fields of ecology and evolutionary biology, in evolutionary medicine, and in evolutionary functional genomics. He came to Yale in 2000 from the University of Basel, Switzerland, where he had been professor of zoology since 1983 and held several administrative ...

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Format:PaperbackDimensions:368 pages, 9.69 × 7.44 × 0.75 inPublished:November 26, 2007Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199207461

ISBN - 13:9780199207466

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Table of Contents

PrefacePart I. Introduction1. Stephen C. Stearns, Randolph M. Nesse, and David Haig: Introducing evolutionary thinking for medicinePart II. The history and variation of human genes2. Jean-Francois Guegan, Franck Prugnolle, and Frederic Thomas: Global spatial patterns of infectious diseases and human evolution3. Diddahally R. Govindaraju and Lynn B. Jorde: Medically relevant variation in the human genome4. Michael Bamshad and Arno G. Motulsky: Health consequences of ecogenetic variation5. Kenneth K. Kidd and Judith R. Kidd: Human genetic variation of medical significancePart III. Natural selection and evolutionary conflicts6. David Haig: Intimate relations: evolutionary conflicts of pregnancy and childhood7. Richard G. Bribiescas and Peter T. Ellison: How hormones mediate tradeoffs in human health and disease8. Dagan A. Loisel, Susan C. Alberts, and Carole Ober: Functional significance of MHC variation in mate choice, reproductive outcome, and disease risk9. Beverly I. Strassmann and Ruth Mace: Perspectives on human health and disease from evolutionary and behavioral ecologyPart IV. Pathogens: resistance, virulence, variation, and emergence10. Carl T. Bergstrom and Michael Feldgarden: The ecology and evolution of antibiotic resistant bacteria11. Andrew F. Read and Margaret J. Mackinnon: Pathogen evolution in a vaccinated world12. Dieter Ebert and James J. Bull: The evolution and expression of virulence13. Paul M. Sharp, Elizabeth Bailes, and Louise V. Wain: Evolutionary origins of diversity in human viruses14. Daniel Dykhuizen and Awdhesh Kalia: The population structure of pathogenic bacteria15. Julian Parkhill: Whole-genome analysis of pathogen evolution16. Mark Woolhouse and Rustom Antia: Emergence of new infectious diseases17. Jacob C. Koella and Paul Turner: Evolution of parasitesPart V. Noninfectious and degenerative disease18. Martin Ackermann and Scott D. Pletcher: Evolutionary biology as a foundation for studying aging and aging-related disease19. Christopher W. Kuzawa, Peter D. Gluckman, Mark A. Hanson, and Alan S. Beedle: Evolution, developmental plasticity, and metabolic disease20. William R. Leonard: Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks21. Mel Greaves: Cancer: evolutionary origins of vulnerability22. Natalia L. Komarova and Dominik Wodarz: Cancer as a microevolutionary process23. Steven N. Austad and Caleb E. Finch: The evolutionary context of human aging and degenerative diseaseReferencesIndex

Editorial Reviews

`'...This book and others like it should help evolutionary thinking permeate medicine more rapidly''Parasitology Today