Ex Vivo Cell Therapy

Hardcover | June 18, 1991

byKlaus SchindhelmEditorRobert Nordon

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Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, or other conditions such as cancer or genetic diseases. These manipulations include the purification and culture of therapeutic cell subtypes, as well as elimination of cells which cause disease cancer cells or immune cells reacting to the body itself . Gene therapy can be delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, cancer or genetic diseases. For small-scale laboratory methods to become clinically applicable processes, these new therapies require efficient technologies for cell separation, cell production in culture and gene transfer. This book integrates the recent advances in biological and clinical research with developments in cell-based technologies to provide a comprehensive review for clinicians, researchers, biotechnologists and biomedical engineers working in this rapidly developing area. The biotechnology and pharmaceutical industry requires a broad perspective for development of future technologies, and this text will provide then with an excellent overview of this rapidly evolving field. Key Features* Comprehensive review by leading researchers* Hematopoietic stem cell development: transcriptional control, signaling pathways, hematopoietic growth factors and adhesion molecules* Clinical developments: hematopoietic stem cell transplantation, cellular immunotherapy and gene therapy* Enabling technologies: cell separation, bioreactors, and gene transfer regulatory issues

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From the Publisher

Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, ...

From the Jacket

Advances in the fields of molecular and cellular biology have led to new therapies that are based on cells as therapeutic agents. Future development of hematopoietic stem cell transplantation, adoptive cellular immunotherapy and gene therapy will rely on safe, economical and scalable technologies that transform current laboratory metho...

Klaus Schindhelm received his PhD in chemical engineering in 1978 at the University of New South Wales with a dissertation on patient hemodialysis interactions. The main focus of his research has been the manipulation of body fluids for extra-corporeal therapies ranging from hemodialysis to therapeutic immunoadsorption systems. This wo...
Format:HardcoverDimensions:356 pages, 9 × 6 × 0.98 inPublished:June 18, 1991Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0126249601

ISBN - 13:9780126249606

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Table of Contents

R.E. Nordon and K. Schindhelm, Introduction.
L. Robb, A.G. Elefanty, and C.G. Begley, Transcriptional Control of Hematopoieses.
R. Starr and N.A. Nicola, Cell Signaling by Hemopoietic Growth Factor Receptors.
P.J. Simmons, D.N. Haylock, and J.-P. Lévesque, Influence of Cytokines and Adhesion Molecules on Hematopoietic Stem Cell Development.
P.A. Rowlings, Allogeneic Hematopoietic Stem Cell Transplantation.
U. Hahn and L.B. To, Autologous Stem Cell Transplantation.
M.R. Vowels, Cord Blood Stem Cell Transplantation.
S.R. Riddell, E.H. Warren, D. Lewinsohn, C. Yee, and P.D. Greenberg, Reconstitution of Immunity by Adoptive Immunotherapy with T Cells.
L.Q. Sun, M. Miller, and G. Symonds, Exogenous Gene Transfer into Lymphoid and Hematopoietic Progenitor Cells.
C. Dowding, T. Leemhuis, A. Jakubowski, and C. Reading, Process Development forEx VivoCell Therapy.
R.E. Nordon and K. Schindhelm, Cell Separation.
P.W. Zandstra, C.J.Eaves, and J.M. Piret, Environmental Requirements of Hematopoietic Progenitor Cells inEx VivoExpansion Systems.
R. Mandalam, M. Koller, and A. Smith, Ex VivoHematopoietic Cell Expansion for Bone Marrow Transplantation.
M. Raponi and G. Symonds, Gene Delivery Technology: Nonviral and Viral Vector Systems.
R.E. Nordon and K. Schindhelm, Summary and Future Directions.
Index.