Excitatory Amino Acid Transmission In Health And Disease

Hardcover | October 6, 2005

byRobert Balazs, Richard J. Bridges, Carl W. Cotman

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Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). It regulates normal CNS function, is a major participant in pathology, and serves learning, memory, and higher cognitive functions. The 12 chapters of this book provide the first comprehensivecoverage of all the major features of glutamate as excitatory neurotransmitter. The book begins with a valuable historical backdrop. Building from a chapter on the common structure of glutamate receptors, several others cover the major ionotropic receptors, their structure, function, andpharmacology. A follow-up chapter discusses the metabotropic receptors that are directly coupled to second messenger metabolism. A central theme of the book is the capacity of the excitatory amino acid system to contribute to the diverse array of signaling systems in the CNS as a direct result ofthe large assortment of receptors (including, for the ionotropic receptors, various subunits) the combination of which determine distinct functional properties. A recent development in the field discussed in several chapters is the biochemical characterization of a supermolecular protein complex,the post-synaptic density, that makes the unique structure of excitatory synapses. This complex subserves the experience-dependent modulation of synaptic strength and synaptic plasticity, and gives the synapse the capacity to change dynamically in both structure and receptor composition. Drawingon the individual properties of the receptors, transporters, and functional architecture of the synapse, the concluding chapters describe the functional integration of these components in the more complex physiological processes of plasticity and pathology. Recognition that the regulation ofexcitatory amino acid receptor activity underlies the pathology of many neurological diseases, including stroke, Alzheimer's disease and schizophrenia, has opened up an exciting frontier that will allow the translation of our understanding of these basic mechanisms into new concepts of pathology andnew therapeutic strategies. This book will be invaluable for neuroscientists, pharmacologists, neurologists, and psychiatrists, and for their students and trainees.

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From the Publisher

Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS). It regulates normal CNS function, is a major participant in pathology, and serves learning, memory, and higher cognitive functions. The 12 chapters of this book provide the first comprehensivecoverage of all the major features of glutama...

Robert Balazs is at University of California at Irvine. Richard J. Bridges is at University of Montana.
Format:HardcoverDimensions:384 pages, 6.42 × 9.09 × 0.98 inPublished:October 6, 2005Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195150023

ISBN - 13:9780195150025

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Table of Contents

1. Introduction: Overview and Perspective2. General Characteristics of Ionotrope glutamate receptors3. AMPA Receptors4. Kainate Receptors5. NMDA Receptors6. Delta Glutamate Receptors7. Metabotropic glutamate receptors8. Glutamate Transporters9. Molecular Organization of Glutamate Receptors in the Postsynaptic Density Complex10. Trafficking of Glutamate Receptors11. Excitatory Amino Acid Transmission and Synaptic Plasticity11. Excitatory Amino Acid Transmission and Synaptic Plasticity12. Glutamate and Glutamate Receptors in Neurological Diseases

Editorial Reviews

"This book will serve not only as a primer for students learning glutamate biology but also be a part of a neuroscientist's, neurologist's, or psychiatrist's arsenal of references as a comprehensive, current, and well organized book with a specific focus on glutamate and disease."--Doody's