Experimental and Clinical Neurotoxicology

Hardcover | March 15, 2000

EditorPeter S. Spencer, Herbert H. Schaumburg, Albert C. Ludolph

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Two decades have passed since publication of the first edition of Experimental and Clinical Neurotoxicology pioneered the development of this discipline. Since then no other book has approached the breadth, scholarship, and balance of that landmark volume. For this long-awaited second edition,the original editors have been joined by Albert Ludolf, who brings expertise in biological neurotoxicology, and together with their distinguished contributors they have completely rewritten and reorganized the text. The scientific and clinical foundation is laid in three comprehensive introductory chapters. An overview of the biological basis of neurotoxicity provides the goundwork for discussing the scope of human and veterinary neurotoxic disease.The bulk of the text is devoted to an alphabeticaltreatment of chemicals with neurotoxic potential. This consists of tightly written overviews of the properties, actions, and mechanisms of all manner of substances, whether natural or synthetic. The neurotoxic side effects of experimental agents and of therapeutic as well as abused drugs arecovered extensively. Environmental pollutants, workplace contaminants, personal-use products, food additives, and agents harbored by plants, animals, and humans for use against their respective enemies are discussed. Each substance is rated on a three-point scale for the weight of evidenceindicating a specific neurotoxic effect in humans, animals, or laboratory models. These effects are summarized and cross-referenced in a series of appendices and an extensive index. In summary, the second edition establishes neurotoxicology as a scientific discipline that melds neurobiology, toxicology, and neurology. From this unique vantage point, the book examines in encyclopedic manner several hundred chemicals with the capacity to induce neurological illness in humansand animals. Indispensable for the experimental neuroscientist and toxicologist, as well as for practitioners of human and animal medicine, the book also provides an authoritative, critical, and pithy reference work for specialists in public health and the legal profession.

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Two decades have passed since publication of the first edition of Experimental and Clinical Neurotoxicology pioneered the development of this discipline. Since then no other book has approached the breadth, scholarship, and balance of that landmark volume. For this long-awaited second edition,the original editors have been joined by Al...

Peter S. Spencer is at Oregon Health Sciences University. Herbert Schaumburg is at Albert Einstein College of Medicine.

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Format:HardcoverPublished:March 15, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195084772

ISBN - 13:9780195084771

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Table of Contents

Part I: Fundamentals of Experimental and Clinical Neurotoxicology1. Peter S. Spencer: Biological Principles of Chemical Neurotoxicity2. Herbert H. Schaumburg: Human Disease3. Anthony A. Frank, Linda L. Blythe, and Peter S. Spencer: Aspects of Veterinary NeurotoxicityPart II: Chemicals with Neurotoxic PotentialThis section presents an encyclopedic description of 450 exogenous neurotoxic chemicals/ mixtures, beginning with Absinthe and ending with Zolpidem.

Editorial Reviews

"The new edition of this book is long overdue and will be warmly welcomed. The book has been expanded and reorganized, and now covers an enormous spectrum of neurotoxic disorders. It is clear that this book will rapidly become the standard reference in the field, and deservedly so. It willfill an important role for many years to come. Its encyclopedic nature, will make it an important addition to all institutional libraries, as well as an invaluable resource to those with a special interest in neurotoxicology." -- Michael Aminoff MD, Muscle and Nerve, Dec 2000