Extracellular Matrix: A Practical Approach

Paperback | April 30, 1999

EditorM. A. Haralson, John R. Hassell

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The extracellular matrix surrounds cells and tissues. It provides structure to organisms and is important in determining cell growth, state of differentiation, and how the cell responds during injury and development. Changes in the extracellular matrix are also important components in bothinherited and acquired diseases. Thus studies of the extracellular matrix span much of modern biological research. Because the extracellular matrix resides outside the cell, the properties of the component molecules require special approaches for their study. This volume brings together under asingle cover the majority of the basic techniques employed in extracellular matrix research.

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From the Publisher

The extracellular matrix surrounds cells and tissues. It provides structure to organisms and is important in determining cell growth, state of differentiation, and how the cell responds during injury and development. Changes in the extracellular matrix are also important components in bothinherited and acquired diseases. Thus studies o...

From the Jacket

The importance of the extracellular matrix in maintaining the structural integrity of organisms, in regulating the normal biology of a cell, and in the development and progression of disease, has established this area as a major focus of contemporary research. This book is a timely compendium of the key biochemical, immunological, and ...

M. A. Haralson is at Vanderbilt University, Nashville, Tennessee. J. R. Hassell is at University of Pittsburgh, Pennsylvania.
Format:PaperbackDimensions:432 pages, 9.21 × 6.14 × 0.91 inPublished:April 30, 1999Publisher:Oxford University Press

The following ISBNs are associated with this title:

ISBN - 10:0199632200

ISBN - 13:9780199632206

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Table of Contents

1. Overview of the different collagen types and approaches for the isolation and characterization of types I, III, V and VI molecules from tissues and cultured cells2. Approaches for isolating and characterizing the collagens in cartilage3. Techniques for evaluating the matrix components found in basement membranes4. Approaches for investigating the specialized matrix components produced by endothelial cells5. Techniques for the isolation and characterization of the enzymes involved in the post-translational processing of collagen6. Techniques for the study of fibronectin and tenascin7. Approaches for the study of glycosaminoglycans8. Approaches for the evaluation of proteoglycans9. Techniques for the use of the extracellular matrix and its components in cell culture10. Approaches for investigating elastin11. Techniques for evaluating the catabolism of extracellular matrix components12. Immunological approaches for the identification of extracellular matrix components in tissues and cultured cells13. Molecular biological approaches for studying extracellular matrix production

Editorial Reviews

`This book sets out to provide the research worker with a comprehensive survey and detailed protocols of the biochemical techniques used for studying the macromolecules of the extracellular matrix. The senior authors of all the chapters are well established in the field of their contribution.This is a strong recommendation for a book which should become a standard handbook for anyone working in this field, particularly those just entering or wishing to develop new techniques.'Doreen E. Ashhurst, St George's Hospital Medical School, Cell Biology International, Vol. 20, No. 9, 1996