Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological…

Other | September 1, 2003

bySchwiebert, Erik Mills, Erik Mills Schwiebert

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Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors.

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* Organized and written by world-renowned experts
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From the Publisher

Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called...

Format:OtherDimensions:497 pages, 1 × 1 × 1 inPublished:September 1, 2003Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0080490972

ISBN - 13:9780080490977

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Table of Contents

Extracellular Nucleotide and Nucleoside Signaling: First Principles
Introduction: ATP and its Metabolites as Potent Extracellular Agents
Cellular Mechanisms and Physiology of Nucleotide and Nucleoside Release from Cells: Current
Knowledge, Novel Assays to Detect Purinergic Agonists, and Future Directions
Molecular and Biological Properties of P2Y Receptors
Extracellular ATP-gated P2X Purinergic Receptor Channels
Molecular and Cell Biology of Adenosine Receptors
Relating the Structure of ATP-gated Ion Channel-receptors to their Function
Epithelial Purinergic Receptors and Signaling in Health and Disease
Nucleotide Release and Purinergic Signaling in the Vasculature Driven by the Red Blood Cell
A Purine Signal for Functional Hyperemia in Skeletal and Cardiac Muscle
Purinergic Receptors in the Nervous System
Purinergic (P2) Receptors in the Kidney
Purinergic Receptors and Hepatobiliary Function
ATP in the Treatment of Advanced Cancer
Purinergic Receptors in the Glomerulus and Vasculature of the Kidney