Familial Breast and Ovarian Cancer: Genetics, Screening and Management by Patrick J. MorrisonFamilial Breast and Ovarian Cancer: Genetics, Screening and Management by Patrick J. Morrison

Familial Breast and Ovarian Cancer: Genetics, Screening and Management

EditorPatrick J. Morrison, Shirley V. Hodgson, Neva E. Haites

Paperback | July 21, 2005

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This publication surveys the profound and far-reaching ramifications that have arisen from the very significant advances in understanding the genetic basis of familial breast and ovarian cancer. Written by international experts from Europe and North America, this book provides the busy clinician with a contemporary and wide-ranging guide to the latest developments in diagnosis, genetics, screening, prevention, and management. In addition, the volume discusses ethical and insurance issues, distinct cultural differences in breast cancer and use of recently devised cancer genetics clinics. The different referral criteria and patterns to these clinics are detailed.
Consultant clinical geneticist with a special interest in cancer genetics, in the Northern Ireland Regional Genetics Service. Qualified MB BCh BAO in 1986 and MD in 1993 from Queens' University Belfast. Held molecular biology and neurogenetics research fellowships from the Royal College of Physicians in Ireland from 1991-1994. Member o...
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Title:Familial Breast and Ovarian Cancer: Genetics, Screening and ManagementFormat:PaperbackDimensions:420 pages, 9.72 × 6.85 × 0.87 inPublished:July 21, 2005Publisher:Cambridge University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0521017777

ISBN - 13:9780521017770

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Table of Contents

Part I. Molecular Biology and Natural History: 1. Introduction Patrick Morrison, Shirley Hodgson and Neva Haites; 2. Overview of clinical genetics of breast cancer Neva Haites and Helen Gregory; 3. Cowden syndrome and related disorders Charis Eng; 4. Overview of clinical genetics of ovarian cancer Pierre Chappuis and Will Foulkes; 5. Ovarian cancer as part of HNPCC and other hereditary colon cancer syndromes Hans Vasen and M. A. Nooy; 6. Natural history of hereditary breast cancer Dominique Stoppa-Lyonnet, Will Foulkes and Pierre Chappuis; 7. Pathology of the breast and ovary in mutation carriers Sunil Lakhani and Adrienne M. Flanagan; 8. Risk estimation for familial breast and ovarian cancer Jenny Chang-Claude and Heiko Becher; Part II. Screening: 9. Experience of setting up a cancer genetics service Jonathon Gray; 10. Referral criteria for cancer genetics clinics Diana Eccles; 11. Service aspects of cancer genetic clinics Neva Haites and Shirley Hodgson; 12. Cultural and education aspects influencing development of cancer genetics services in different European countries Shirley Hodgson; 13. Screening, detection and survival patterns of breast and other cancers in high risk families Pål Møller and Michael Steel; 14. Screening for familial ovarian cancer Barnaby Rufford, Usha Menon and Ian Jacobs; Part III. Management: 15. Management of BRCA 1/2 mutation carriers Pierre Chappuis and Will Foulkes; 16. Management of ovarian cancer Dirk Brinkman and Ian Jacobs; 17. Prophylactic mastectomy in mutation carriers Gareth Evans, Fiona Lalloo and Andrew Balidam; 18. Psychosocial aspects of genetic counselling Steven Sutton and Alison Bish; 19. BRCA 1 and 2 testing: uptake and its measurement Lucy Brooks and Gareth Evans; 20. Ethical aspects Patrick Morrison and Michael Steel; 21. Gene therapy of breast and ovarian cancer Richard Kennedy and Patrick Johnston; 22. Future directions Patrick Morrison, Shirley Hodgson and Neva Haites.

Editorial Reviews

"Over all, the text is very readable for a general scientific audience....This edited text covers all of the major areas of interest in considering familial and hereditary breast and ovarian cancers. Although the editors, most authors, and the focus on services are European, there are enough commonalities to make the book a worthwhile purchase for North American readers as well." American Journal of Human Genetics