Fetal And Neonatal Physiology, 2-volume Set

Hardcover | July 1, 2016

byRichard A. Polin, Steven H. Abman, David Rowitch

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Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this2-volume resource continues to serve as an excellent reference tool, focusing on thebasic science needed for exam preparation and thekey information required forfull-time practice.

The 5thedition is themost substantially updated and revised edition ever . In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease;Fetal and Neonatal Physiology synthesizes this knowledge intodefinitive guidance for today's busy practitioner.

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Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this2-volume resource continues to serve as an excellent reference tool, focusing on thebasic science needed for exam preparation ...

Format:HardcoverDimensions:1928 pages, 9.41 × 7.24 × 0.98 inPublished:July 1, 2016Publisher:Elsevier CanadaLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0323352146

ISBN - 13:9780323352147

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Table of Contents

Section I - Genetics and Embryology

  1. Basic Genetic Principles
  2. Prenatal Diagnosis
  3. Basic Embryology
  4. Regulation of Embryogenesis
  5. The Extracellular Matrix in Development
  6. Stem Cell Biology
  7. Apoptotic Cell Death
  8. Angiogenesis
  9. Epigenetics
  10. Section II - Placenta and Intrauterine Environment

  11. Placental Development
  12. Regulation of the Placental Circulation
  13. Mechanisms of Transfer Across the Human Placenta
  14. Endocrine and Paracrine Function of the Human Placenta
  15. Fetal and Maternal Responses to Intrauterine Infection
  16. Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance
  17. Physiologic Effects of Multiple Pregnancy on Mother and Fetus
  18. Placental function in intrauterine growth restriction
  19. Section III - Developmental Pharmacology and Pharmacokinetics

  20. Basic Pharmacologic Principles
  21. Principles of Pharmacokinetics
  22. Physicochemical and Structural Properties Regulating Placental Drug Transfer
  23. Pharmacogenetics
  24. Drug Distribution in Fetal Life
  25. Drug Transfer During Breastfeeding
  26. Section IV - Intrauterine and Postnatal Growth

  27. Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction
  28. Endocrine Factors Affecting Neonatal Growth
  29. Human Milk Composition and Function in the Infant
  30. Physiology of Lactation
  31. Section V - Perinatal Iron, Mineral, and Vitamin Metabolism

  32. Fetal and Neonatal Iron Metabolism
  33. Neonatal Calcium, Phosphorus, and Magnesium Homeostasis
  34. Zinc in the Fetus and Neonate
  35. Vitamin A Metabolism in the Fetus and Neonate
  36. Vitamin E Metabolism in the Fetus and Newborn Infant
  37. Vitamin K Metabolism in the Fetus and Neonate
  38. Section VI - Lipid Metabolism

  39. Maternal-Fetal Transfer of Lipid Metabolites
  40. Brown Adipose Tissue: Development and Function
  41. Lipids as an Energy Source for the Premature and Full-Term Neonate
  42. Ketone Body Production and Metabolism in the Fetus and Neonate
  43. Long-Chain Fatty Acids in the Developing Retina and Brain
  44. Section VII - Carbohydrate Metabolism

  45. Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn
  46. Carbohydrate Metabolism During Pregnancy
  47. Oxygen Consumption and General Carbohydrate Metabolism of the Fetus
  48. Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period
  49. Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development
  50. Section VIII - Protein Metabolism

  51. General Concepts of Protein Metabolism
  52. Fetal Requirements and Placental Transfer of Nitrogenous Compounds
  53. Section IX - Thermoregulation

  54. Temperature Control in Newborn Infants
  55. Responses of the Fetus and Neonate to Hypothermia
  56. Section X - Skin

  57. Structure and Development of Skin and Cutaneous Appendages
  58. Physiologic Development of the Skin
  59. Section XI - Fetal and Neonatal Cardiovascular Physiology

  60. Cardiovascular Development
  61. Developmental Electrophysiology in the Fetus and Neonate
  62. Developmental Biology of the Pulmonary Vasculature
  63. Development of the Gastrointestinal Circulation in the Fetus and Newborn
  64. Physiology of Congenital Heart Disease in the Neonate
  65. Neural Regulation of Blood Pressure During Fetal and Newborn Life
  66. Developmental Effects on Fetal Circulation
  67. Mechanisms Regulating Closure of the Ductus Arteriosus
  68. Umbilical Circulation
  69. Fetal and Placental Circulation During Labor
  70. Physiology of Resuscitation
  71. Section XII - The Lung

  72. Normal and Abnormal Structural Development of the Lung
  73. Regulation of Alveolarization
  74. Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth
  75. Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis
  76. Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung
  77. Upper Airway Structure: Function, Regulation, and Development
  78. Regulation of Lower Airway Function
  79. Functional Development of Respiratory Muscles
  80. Mechanics of Breathing
  81. Pulmonary Gas Exchange in the Developing Lung
  82. Oxygen Transport and Delivery
  83. Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate
  84. Basic Mechanisms of Oxygen Sensing and Response to Hypoxia
  85. Evaluation of Pulmonary Function in the Neonate
  86. Mechanisms of Neonatal Lung Injury
  87. Impaired Lung Growth After Injury in Premature Lung
  88. Antenatal Factors That Influence Postnatal Lung Development and Injury
  89. Regulation of Pulmonary Circulation
  90. Section XIII - Surfactant

  91. Historical Perspective
  92. Composition of Pulmonary Surfactant Lipids and Proteins
  93. Structure And Development of Alveolar Epithelial Cells
  94. Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion
  95. Hormonal Therapy for Prevention of Respiratory Distress Syndrome
  96. Surfactant Treatment
  97. Genetics and Physiology of Surfactant Protein Deficiencies
  98. Section XIV - Physiology of Gastrointestinal Tract in the Fetus and Neonate

  99. Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development
  100. Organogenesis of the Gastrointestinal Tract
  101. Development of the Enteric Nervous System
  102. Development of Gastric Secretory Function
  103. Development of Gastrointestinal Motility
  104. Development of the Exocrine Pancreas
  105. Digestive-Absorption Functions in Fetuses, Infants, and Children
  106. Development of the Intestinal Microbiome
  107. Section XV - Liver and Bilirubin Metabolism

  108. Organogenesis and Histologic Development of the Liver
  109. Bile Acid Metabolism During Development
  110. Neonatal Bilirubin Metabolism
  111. Hereditary Contribution to Neonatal Hyperbilirubinemia
  112. Mechanisms of Action of Phototherapy for Neonatal Hyperbilirubinemia
  113. Section XVI - The Kidney

  114. Embryogenesis and Anatomic Development of the Kidney
  115. Functional Development of the Kidney in Utero
  116. Development and Regulation of Renal Blood flow in the Neonate
  117. Development of the Renin-Angiotensin System
  118. Postnatal Development of Glomerular Filtration Rate in Neonates
  119. Renal Transport of Sodium During Early Development
  120. Potassium Homeostasis in the Fetus and Neonate
  121. Role of the Kidney in Calcium and Phosphorus Homeostasis
  122. Transport of Amino Acids in the Fetus and Neonate
  123. Developmental Aspects of Organic Acid Transport
  124. Concentration and Dilution of the Urine
  125. Development of Acidification Mechanisms in the Fetus and Neonate
  126. Response to Nephron Loss in Early Development
  127. Section XVII - Fluid and Electrolyte Metabolism

  128. Fluid Distribution in the Fetus and Neonate
  129. Regulation of Acid-Base Balance in the Fetus and Neonate
  130. Section XVIII - Developmental Hematopoiesis

  131. Developmental Biology of Stem Cells: From the Embryo to the Adult
  132. Developmental Granulocytopoiesis
  133. Developmental Erythropoiesis
  134. Developmental Megakaryocytopoiesis
  135. Section XIX - Hemostasis

  136. Developmental Hemostasis
  137. Platelet Vessel Wall Interactions
  138. Section XX - Developmental Immunobiology

  139. Host Defense Mechanisms Against Bacteria
  140. Host-Fungi Interactions Relevant to the Newborn Infant
  141. Host Defense Mechanisms Against Viruses
  142. T-Cell Development
  143. B-Cell Development
  144. Mononuclear Phagocyte System
  145. Normal and Abnormal Neutrophil Physiology in the Newborn
  146. The Complement System of the Fetus and Newborn
  147. Cytokines and Inflammatory Response in the Fetus and Neonate
  148. Immunology of Human Milk and Host Immunity
  149. Neonatal Pulmonary Host Defense
  150. Section XXI - Neurology

  151. Development of the Nervous System
  152. Development of the Blood-Brain Barrier
  153. Trophic Factor and Nutritional and Hormonal Regulation of Brain Development
  154. Intraventricular Hemorrhage in the Neonate
  155. Cerebellar Development an Impact of Preterm Birth and Co-Morbidities
  156. Electroencephalography in the Premature and Full-Term Infant
  157. Developmental Aspects of Pain
  158. Section XXII - Special Sensory Systems in the Fetus and Neonate

  159. Early Development of the Human Auditory System
  160. Development of Taste and Smell in the Neonate
  161. Section XXIII - Orthopedics

  162. The Growth Plate: Embryologic Origin, Structure, and Function
  163. Ontogenesis of Striated Muscle
  164. Section XXIV - Endocrine Function

  165. Hypothalamus: Neuroendometabolic Center
  166. Growth Factor Regulation of Fetal Growth
  167. Growth Hormone in the Fetus and Newborn
  168. Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn
  169. Development of the Corticotropin-Releasing Hormone Corticotropin System in the Mammalian Fetus
  170. Fetal and Neonatal Adrenocortical Physiology
  171. Fetal and Neonatal Thyroid Physiology
  172. Section XXV - Ovary and Testis

  173. Genetics of Sex Determination and Differentiation
  174. Differentiation of the Ovary
  175. Testicular Development and Descent
  176. Section XXVI - Pathophysiology of Neonatal Diseases

  177. Pathophysiology of Neonatal sepsis
  178. Pathophysiology of Hypoglycemia in the Neonate
  179. Pathophysiology of Cardiomyopathies
  180. Pathophysiology of Persistent pulmonary hypertension of the newborn
  181. Pathophysiology of Shock in the Fetus and Neonate
  182. Pathophysiology of Apnea of Prematurity
  183. Pathophysiology of Respiratory Distress Syndrome
  184. Pathophysiology of Meconium Aspiration Syndrome
  185. Pathophysiology of Bronchopulmonary Dysplasia
  186. Pathophysiology of Ventilator Dependent Infants
  187. Pathophysiology of Gastroesophageal Reflux
  188. Pathophysiology of Neonatal Necrotizing Enterocolitis
  189. Pathophysiology of Kernicterus
  190. Pathophysiology of neonatal acute kidney injury
  191. Pathophysiology of Edema
  192. Pathophysiology of Retinopathy of Prematurity
  193. Pathophysiology of Hypoxic-ischemic Brain Injury
  194. Pathophysiology of Neonatal White Matter Injury
  195. Pathophysiology of Meningitis
  196. Pathophysiology of Neural Tube Defects
  197. Pathophysiology of Preeclampsia
  198. Pathophysiology of Preterm Birth
  199. Pathophysiology of Chorioamnionitis