Fibrinolytics and Antifibrinolytics by F. BachmannFibrinolytics and Antifibrinolytics by F. Bachmann

Fibrinolytics and Antifibrinolytics

EditorF. Bachmann

Paperback | February 27, 2012

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This book covers basic aspects of the molecular biology, biochemistry and pharmacology of the plasminogen-plasmin (fibrinolytic) system. Individual chapters, written by well-known experts in the field, are devoted to plasminogen and its activation, the tissue-type plasminogen activator (tPA), the urinary-type-plasminogen activator (uPA), inhibitors of the fibrinolytic system, and the assembly of fibrinolytic constituents on cell surfaces. The major part of the book deals with the therapeutic use of thrombolytic agents in myocardial infarction, deep venous thrombosis, pulmonary embolism, peripheral arterial occlusions and stroke. The newest thrombolytic agents are discussed in depth. Results of major clinical trials up to the end of 1999 are critically evaluated. The volume is a modern up-to-date presentation of the entire field of the treatment of arterial and venous thromboses with thrombolytic agents.
Title:Fibrinolytics and AntifibrinolyticsFormat:PaperbackDimensions:625 pages, 9.25 × 6.1 × 0.07 inPublished:February 27, 2012Publisher:Springer Berlin HeidelbergLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:3642630294

ISBN - 13:9783642630293

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Table of Contents

Sect. I: Molecular Biology, Biochemistry, Physiology, and Pharmacology of the Plasminogen-Plasmin Enzyme System 1. The Fibrinolytic System and Thrombolytic Agents.- 2. Plasminogen and Streptokinase.- 3. Tissue-type Plasminogen Activator (tPA).- 4. Urinary-type Plasminogen Activator (uPA).- 5. The Inhibitors of the Fibrinolytic System.- 6. Assembly of the Plasminogen System on Cell Surfaces. Section II: Clinical Use of Thrombolytic Agents - In Acute Myocardial Infarction.- 7. Streptokinase and Anisoylated Lys-Plasminogen Streptokinase Activator Complex.- 8. Tissue-type Plasminogen Activator (tPA).- 9. Urokinase and Single-Chain Urokinase-Type Plasminogen Activator (Pro-urokinase).- 10. Comparative Evaluations of tPA vs SK with Particular Reference to the GUSTO-I Trial.- 11. Conjunctive Therapy to Reduce the Occurrance of Coronary Reocclusion after Thrombolytic Treatment of AMI.- - Thrombolytic Treatment of Other Clinical Thromboembolic Conditions.- 12. New Concepts in Thrombolysis of Pulmonary Embolism.- 13. Deep Venous Thrombosis. 14. Peripheral Arterial Occlusions.- 15. Thrombotic Cerebrovascular Disease.- - Thrombolytic Agents in Development, Biochemistry, Pharmacology, Efficacy in Animal Experiments and First Clinical Trials.- 16. Staphylokinase.- 17. Desmodus rotundus (Common Vampire Bat) Salivary Plasminogen Activator.- 18. Thrombus-Targeting of Plasinogen Activators. 19. The Hunt for the Ideal Thrombolytic Agent: Mutants of tPA and uPA, Chimera of both Molecules, Fibrolase.- 20. Agents which Increase Synthesis and Release of Tissue-Type Plasminogen Activator.- 21. Structure, Pharmacology and Clinical Use of Antifibrinolytic Agents.-