Fmoc Solid Phase Peptide Synthesis: A Practical Approach

Paperback | December 16, 1999

EditorW. Chan, Peter White

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In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work havenow for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linearpeptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. Thedifficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PINsynthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

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In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work havenow for the most part, been solved. As a res...

W. Chan is at University of Nottingham. Peter White is at Calbiochem/Novabiochem (UK), Nottingham.

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Format:PaperbackPublished:December 16, 1999Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0199637245

ISBN - 13:9780199637249

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Table of Contents

PrefaceSheppard: Introduction - a retrospective viewpointWhite and Chan: Basic PrinciplesChan and White: Basic ProceduresAlbericio et al: Preparation and Handling of Peptides Containing Methionine and CysteineQuibell and Johnson: Difficult PeptidesWellings et al: Synthesis of Modified PeptidesWhite: Phosphopeptide SynthesisKihlberg: Glycopeptide SynthesisBarlos and Gatos: Convergent Peptide SynthesisDrijfhout and Hoogerhout: Methods of Preparing Peptide-carrier ConguatesTam and Lu: Chemoselective and Orthogonal Ligation TechniquesMascagni: Purification of Large Peptides Using Chemioselective TagsCammish and Kates: Instrumentation for Automated Solid-Phase Peptide SynthesisDoerner et al: Manual Multiple Synthesis MethodsAppendix OneAppendix TwoAppendix ThreeIndex

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'..a completly fresh book.....a goldmine...' European Petide Society