Foundations of Regenerative Medicine: Clinical and Therapeutic Applications

Other | September 4, 2009

byAnthony Atala, Anthony Atala

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The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today.

Derived from the successfulPrinciples of Regenerative Medicine,this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field.



  • Highlights the fundamentals of regenerative medicine to relate to a variety of related science and technology fields

  • Introductory chapter directly addresses why regenerative medicine is important to a variety of researchers by providing practical examples and references to primary literature

  • Includes new discoveries from leading researchers on restoration of diseased tissues and organs

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From the Publisher

The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and development...

Anthony Atala, M.D., is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues...

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Format:OtherDimensions:824 pages, 1 × 1 × 1 inPublished:September 4, 2009Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123785626

ISBN - 13:9780123785626

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Table of Contents

Preface

I. INTRODUCTION TO REGENERATIVE MEDICINE Current and Future Perspectives of Regenerative medicine Fundamentals of cell-based therapies Stem Cell Research

II. BIOLOGIC AND MOLECULAR BASIS FOR REGENERATIVE MEDICINE Molecular Organization of Cells Cell-ECM interactions In Repair and Regeneration Developmental Mechanisms of Regeneration The molecular basis of pluripotency in Principles of Regenerative Medicine

III. CELLS AND TISSUE DEVELOPMENT Embryonic Stem Cells: Derivation and Properties Stem cells derived from amniotic fluid and placenta Bone Marrow stem cells: Properties and Pluripotency Mesenchymal Stem cells Islet Cell Therapy and Pancreatic Stem Cells Mechanical Determinants of Tissue Development Morphogenesis and Morphogenic Proteins Physical stress as a factor in tissue growth and remodeling Engineering Cellular Microenvironments Applications of Nanotechnology

IV. BIOMATERIALS FOR REGENERATIVE MEDICINE Design Principles in Biomaterials and Scaffolds Naturally Occurring Scaffold Materials Synthetic Polymers Surface Modification of Biomaterials Biocompatibility and Bioresponse to biomaterials

V. THERAPEUTIC APPLICATIONS: Cell Therapy Clinical islet transplantation Cell Based Repair for Cardiovascular Regeneration and Neovascularization Cell therapies for bone regeneration Cell-Based Therapies for Musculoskeletal Repair Hepatocyte Transplantation Cell Based Drug Delivery

VI. THERAPEUTIC APPLICATIONS: Tissue Therapy Engineering of Large Diameter Vessels Cardiac Tissue Intracorporeal Kidney Support Genitourinary System Tissue Engineering of the Reproductive System Phalanges and Small Joints Functional Tissue Engineering of Ligament and Tendon Injuries Skeletal Muscle Peripheral Nervous System Innovative Regenerative Medicine Approaches to Skin Cell Based Therapy for Patients With Burn Injuries

VII. REGULATION AND ETHICS Ethical Considerations To Make Is to Know: The Ethical Issues in Human Tissue Engineering Overview of FDA Regulatory Process Current Issues in US Patent Law