Foundations of the Neuron Doctrine: 25th Anniversary Edition by Gordon M. Shepherd

Foundations of the Neuron Doctrine: 25th Anniversary Edition

byGordon M. Shepherd

Hardcover | November 17, 2015

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The neuron doctrine, first formulated in 1891, states that the brain is constructed of individual neurons, organized into functioning circuits that mediate behavior. It is the fundamental principal that underlies all of neuroscience and clinical neurology. Foundations of the Neuron Doctrinegives an authoritative account of how this theory was the product of an explosion of histological studies and vigorous debates near the end of the nineteenth century by an extraordinary group of scientists, led by Santiago Ramon y Cajal of Spain, using a selective stain discovered by Camillo Golgiof Italy. They were the first to describe the distinctive branching patterns of nerve cells, providing evidence that the cells interact as individual units to form circuits, opposed however by Golgi, who held out for a view that the nerve cells form syncytial networks. Studies in the 1950s appeared to confirmthe nerve cell as an individual unit, as embodied in the neuron doctrine, which became the basis for the rise of concepts of normal and disordered neural function since then. This 25th Anniversary Edition is timely. Recent studies are showing a much greater degree of complexity in neuronal organization, so that the debate of neuron versus network is again coming to the fore in neuroscience research. Unique to this Anniversary Edition is the inclusion of commentaries bydistinguished international leaders - Marina Bentivoglio, Xavier De Felipe, Sten Grillner, Paolo Mazzarello, Larry Swanson, and Rafael Yuste - on the continuing relevance of the neuron doctrine for modern studies of the brain at all levels, from genes and molecules to microcircuits, neural networks,and behavior. As this new wave of modern studies expands our concepts of nervous function as the basis of behavior, Foundations of the Neuron Doctrine will be a unique source providing conceptual continuity from classical times to the present and into the future.With commentaries from:Marina Bentivoglio Paolo Mazzarello Javier DeFelipe Larry Swanson Sten Grillner Rafael Yuste

About The Author

Gordon M. Shepherd is Professor of Neurobiology at Yale University School of Medicine. He carries out research on the olfactory pathway as a simple system for the microcircuit organization of the brain. He is a former Editor-in-Chief of the Journal of Neurophysiology and Journal of Neuroscience. His books include Handbook of Brain Micr...

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Title:Foundations of the Neuron Doctrine: 25th Anniversary EditionFormat:HardcoverDimensions:384 pages, 9.25 × 6.12 × 0.98 inPublished:November 17, 2015Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0190259388

ISBN - 13:9780190259389

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Table of Contents

PrefaceCommentaries on The Neuron DoctrineMarina Bentivoglio: Cajal, Golgi and Ariadne's NeedleJavier DeFelipe: Reflections on the Neuron DoctrineSten Grillner: The Neuron Doctrine Revisited: A Personal AccountPaolo Mazzarello: Camillo Golgi, Foundations of the Neuron Doctrine, and the History of NeurosciencesLarry Swanson: Some Reflections on the Neuron Doctrine1. Introduction2. From the Beginnings to the Cell Theory3. Do Nerve Cells Belong in the Cell Theory?4. Nerve Cells or Nerve Nets?5. Kolliker Gives In6. Support Builds for Network7. The Nerve Cell Studies of Freud8. The Revolutionary Method of Golgi9. A Neuron Theory Begins to Take Form: His, Forel, Nansen10. Ramon y Cajal: The Shock of Recognition11. The Early Discoveries of Cajal12. The Laws of Cajal13. Joining the Mainstream14. The Neuron Doctrine15. The Law of Dynamic Polarization16. Controversy17. The Synapse and the Growth Cone18. Forging a Consensus19. Confrontation in Stockholm20. Modern Revisions of the Neuron DoctrineComment on SourcesReferencesIndex