Free Radicals and Iron: Chemistry, Biology, and Medicine

Hardcover | August 1, 1998

byM. C. R. Symons, J. M. C. Gutteridge

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This concise monograph describes a variety of important reactions of iron in biological free-radical reactions. It presents both a chemical and a biochemical perspective of the topic, but at the same time unifies ideas where possible. Iron plays a key role in biological life processes, as acatalayst enabling us to use oxygen to generate the heat and chemical energy that drives life. When iron is not properly controlled within the body it can cause damage by making free radicals. The authors present a chemical and biomedical perspective of how reactions of iron complexes and freeradicals may contribute to human health and disease, especially in reactions of oxygen and hydrogen peroxide.

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This concise monograph describes a variety of important reactions of iron in biological free-radical reactions. It presents both a chemical and a biochemical perspective of the topic, but at the same time unifies ideas where possible. Iron plays a key role in biological life processes, as acatalayst enabling us to use oxygen to generat...

Martyn Symons is at DeMontfort University. John Gutteridge is at Royal Brompton Hospital.

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Format:HardcoverPublished:August 1, 1998Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198558929

ISBN - 13:9780198558927

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Table of Contents

Part 11. A dedication, some history, and a brief overview2. Free radicals3. Oxygen, hydrogen peroxide, and water4. Iron valence states and ligands5. The Fenton reactionPart 26. Natural iron ligands7. Protection against superoxide, hydrogen peroxide, and ferrous ions8. Superoxide, perioxides, and iron in biological systems9. Iron and human diseases10. Biological measurements and fingerprints of radical and related damageAppendix 1 - List of Fenton's publicationsAppendix 2 - 'Oxidation of Tartaric Acid in the Presence of Iron'Appendix 3 - Movement of Electrons and ProtonsAppendix 4 - The use of spectroscopic techniques in the detection of free-radical intermediatesAppendix 5 - Reduction Potentials