Free Radicals in Biology and Medicine by Barry HalliwellFree Radicals in Biology and Medicine by Barry Halliwell

Free Radicals in Biology and Medicine

byBarry Halliwell, John M. C. Gutteridge

Paperback | September 20, 2015

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Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss "in vivo" and"dietary" antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plantsagainst pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailedand critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.
Barry Halliwell is Senior Advisor to the President and Tan Chin Tuan Centennial Professor at National University of Singapore.
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Title:Free Radicals in Biology and MedicineFormat:PaperbackDimensions:944 pages, 9.69 × 7.44 × 0.03 inPublished:September 20, 2015Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198717482

ISBN - 13:9780198717485

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Table of Contents

1. Oxygen: Boon yet Bane - introducing oxygen toxicity and reactive species2. Redox chemistry: the essentials3. Antioxidant defences synthesized in vivo4. Antioxidants from the diet5. Oxidative stress and redox regulation: adaptation, damage, repair, senescence and death6. Measurement of reactive species7. Reactive species can pose special problems needing special solutions: some examples8. Reactive species can be useful: some more examples9. Reactive species can be poisonous: their role in toxicology10. Reactive species in disease: friends or foes?11. Ageing, nutrition, disease and therapy: a role for antioxidants?Appendix