From Bench to Market: The Evolution of Chemical Synthesis

Paperback | October 15, 2000

byWalter Cabri, Romano Di Fabio

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Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process ofindustrial chemical synthesis, from the first discovery of a molecule, or 'new chemical entity', to its entry in the marketplace as a drug. They discuss all aspects related to the process research for bulk production, including comparison between different synthetic routes, key methodologies andreaction mechanisms, costs, patent competition, and crystalline forms. The authors use the real chemical history of the development of drugs from several therapeutic areas as detailed case studies, each chosen to illustrate a range of issues and methodologies in industrial chemistry. Severalchapters cover the development of the various ss-lactam antibiotics; two chapters describe the discovery and synthesis of the anticancer drugs Idarubicin and Paclitaxal; in another chapter, the synthesis of the anti-viral drug Acyclovir and the 'patent war' that resulted are explored. Between them,the authors represent considerable first-hand experience in pharmaceutical research and development. The technical, practical, and strategic information they have amassed make this essential reading for graduate and undergraduate chemists intending to work in the pharmaceutical industry, as well asfor industrial chemists themselves. Lecturers teaching courses in medicinal and organic chemistry will also find it useful.

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Who wins the race to turn molecules into medicines? How much does it cost? What factors influence the choice of synthetic routes and reaction mechanisms? How can pharmaceutical companies protect their discoveries? In From Bench to Market, Walter Cabri and Romano Di Fabio chart the process ofindustrial chemical synthesis, from the firs...

Walter Cabri, R+D Director, Research and Development, Antibioticos, Rodano, Italy wcabri@antibioticos.it Romano Di Fabio, Head of CNS Medicinal Chemistry, Medicines and Research Centre, Glaxo- Wellcome, Verona, Italy rdf26781@glaxowellcome.co.uk
Format:PaperbackPublished:October 15, 2000Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0198503830

ISBN - 13:9780198503835

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Table of Contents

Preface1. Process research and development: The modern approach2. Non-classical ss-lactam antibiotics3. Imipenem4. Sanfetrinems5. Ritipenems6. Losartan7. Nabumetone8. Acyclovir9. Idarubicin10. Paclitaxel11. The drug discovery process: Towards a new paradigm

Editorial Reviews

" I highly recommend this book to process chemists not only in the pharmaceutical industry but in the fine chemical, agrochemical, and colour chemical industries too ... highly recommened - I will certainly use it as a teaching aid " Chemistry in Industry