From Development to Degeneration and Regeneration of the Nervous System

Hardcover | December 16, 2008

EditorCharles E. Ribak, Carlos Aramburo de la Hoz, Edward G. Jones

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This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons aregenerated from the ventricular zone in the forebrain and migrate to their destinations in the cerebral cortext. This description of cortical development also includes a discussions of the Cajal-Retzius cell. Another chapter provides insight about the development of another forebrain region, thehypothalamus. The remaining chapters of this section examine the clinical relevance of brain development in certain disease states in humans: neural tube defects and the normal and abnormal development of human electroencephalographic recordings during the first year of age. The second section on degenerative disorders of the brain begins wtih details about the dopaminergic neurons in the substantia niger and their loss in Parkinson's disease. Two subsequent chapters describe changes in brain aging, including changes in the numbers of myelinated axons. Other chapters inthis section describe important cellular and molecular changes found in Alzheimer's disease and human epilepsy. Together, these chapters summarize much of our current knowledge about the major molecular and cellular changes found in several degenerative diseases of the brain. The last section addresses the issues of brain plasticity and regeneration in the adult brain and begins with a chapter on how the brain's own stem cells provide newly generated neurons to the hippocampal dentate gyrus and how these neurons become integrated into neural circuitry. The following twochapters examine some of the neuroplastic changes that take place in motor and sensory cortices of awake behaving primates.The concluding two chapters address the issue of regeneration in the injured spinal cord and the factors that may contribute to its success.

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This book provides current information about the three areas mentioned in the title: Neuronal Migration and Development, Degenerative Brain Diseases, and Neural Plasticity and Regeneration. The chapters about brain development examine the cellular and molecular mechanisms by which neurons aregenerated from the ventricular zone in the f...

Charles E. Ribak, PhD is in the Department of Anatomy and Neurobiology at UC Irvine. Carlos Arumbaro de la Hoz, PhD is at the Instituto de Neurobiologia at Universidad Nacional Autonoma de Mexico. Edward G. Jones, PhD, DPhil is Director, Center for Neuroscience at the University of California, Davis. Dr. Jorge A. Larriva Sahd is at t...

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Format:HardcoverDimensions:408 pages, 5.98 × 9.29 × 0.98 inPublished:December 16, 2008Publisher:Oxford University PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0195369009

ISBN - 13:9780195369007

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Table of Contents

1. Jose Luis Diaz: The Legacy of Cajal in MexicoPart I: Neuronal Migration and Development2. Juan de Carlos and Fernando Garcia-Moreno: Tangential Cell Movements During Early Telencephalic Development3. Amaya Miguelajauregui and Alfredo Varela-Echavarria: Gene Control of Cajal-Retzius Cell Development4. Larry Sawnson: Development of the Paraventricular Nucleus of the Hypothalamus5. Enrique Pedernera, V.R. Nunez, and C. Mendez: Neural Tube Defects: New Insights on Risk Factors6. Thalia Harmony, Alfonso Alba, Jose Luis Marroquin, Antonio Fernandez-Bouzas, Gloria Avecilla, Josefina Ricardo-Garcell, Efrain Santiago-Rodriguez, Gloria Otero, Eneida Porras-Kattz, and Thalia Fernandez: Quantitative Electroencephalography in the Normal and Abnormal Developing Human BrainPart II: Degenerative Brain Diseases7. Kjell Fuxe, Daniel Marcellino, Tiziana Antonelli, Giuseppa Mudo, Paul Manger, Susanna Genedani, Luca Ferraro, Natale Belluardo, Sergio Tanganelli, and Luigi F. Agnatti: The Nigro-Striatal DA Neurons and Mechanisms of their Degeneration in Parkinson's Disease8. Alan Peters: Degeneration and Regeneratino of Myelin in the Central Nervous System of the Aging Monkey9. Elizabeth Head: Degeneration in Canine Brain Again10. Jorge Busciglio and Atul Deshpande: Alzheimer's Disease-Related Mechanisms of Neuronal Dysfunction and Degeneration: Studies in Human Cortical Neurons11. Carlos Cepeda, Veronique M. Andre, Irene Yamazaki, Max Kleiman-Weiner, Robin S. Fisher, Harry V. Winters, Michael S. Levine, and Gary W. Mathern: Aberrant Cells and Synaptic Circuits in Pediatric Epilepsy Surgery PatientsPart III: Neural Plasticity and Regeneration12. Charles E. Ribak, Zachary D. Perez, and Lee A. Shapiro: Developmental Profile of Newly-Generated Granule Cells in the Adult Rodent Dentate Gyrus13. Hugo Merchant, Thomas Naselaris, Wilbert Zarco, Ramon Bartolo, Luis Prado, Oswaldo Perez, Karina Yc, and Juan Carlos Mendez: Functional Architecture of Directional Tuning in the Primate Motor Cortext During 3D Reaching14. Ranulfo Romo, Adrian Hernandez, Luis Lemus, Rogelio Luna, Antonio Zainos, Veronica Nacher, Manuel Alvarez, Yuriria Vasquez, Silvia Cordero, and Liliana Camarillo: Neural Codes for Perceptual Decisions15. Aileen Anderson, Brian J. Cummings, Mitra J. Hooshmand, and Desiree L. Salazar: Human Neural Stem Cell Mediated Repair of the Contused Spinal Cord: Timing the Microenvironment16. Hans Keirstead and Monica M. Siegenthaler: Spinal Cord Injury Pathology Differs wtih Injury Type, Age, and Exercise

Editorial Reviews

"...a complete account of the evolution of the field that in over 100 years of development transformed the way we envision neuroscience." --Doody's