From Molecules To Networks: An Introduction To Cellular And Molecular Neuroscience by John H. Byrne

From Molecules To Networks: An Introduction To Cellular And Molecular Neuroscience

byJohn H. ByrneEditorRuth Heidelberger, M. Neal Waxham

Hardcover | July 11, 2014

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An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition ofFrom Molecules to Networksprovides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced.

All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography).

Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results.



  • The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches
  • 80% updated and new content
  • New Chapter on "Biophysics of Voltage-Gated Ion Channels"
  • New Chapter on "Synaptic Plasticity"
  • Includes a chapter on the Neurobiology of Disease
  • Highly referenced, comprehensive and quantitative
  • Full color, professional graphics throughout
  • All graphics are available in electronic version for teaching purposes

About The Author

The June and Virgil Waggoner Professor and Chair, Department of Neurobiology and Anatomy, University of Texas Medical School at Houston. Dr. Byrne is an internationally acclaimed Neuroscientist. He received his PhD under the direction of Noble Prize winner, Eric Kandel. Dr. Byrne is a prolific author and Editor-in-Chief of Learning and...
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Title:From Molecules To Networks: An Introduction To Cellular And Molecular NeuroscienceFormat:HardcoverDimensions:694 pages, 9.41 × 7.24 × 0.98 inPublished:July 11, 2014Publisher:Academic PressLanguage:English

The following ISBNs are associated with this title:

ISBN - 10:0123971799

ISBN - 13:9780123971791

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Table of Contents

SECTION I. CELLULAR AND MOLECULAR 1. Cellular Components of Nervous Tissue - Patrick R. Hof, Graham Kidd, Javier DeFelipe, Jean de Vellis, Miguel A. Gama Sosa, Gregory A. Elder and Bruce D. Trapp 2. Subcellular Organization of the Nervous System: Organelles and Their Functions - Scott Brady and Peter Brophy 3. Energy Metabolism in the Brain - Gerald Dienel 4. Intracellular Signaling - Howard Schulman 5. Regulation of Neuronal Gene Expression and Protein Synthesis - Cristina Alberini and Eric Klann 6. Modeling and Analysis of Intracellular Signaling Pathways - Paul D. Smolen, Douglas A. Baxter and John H. Byrne 7. Pharmacology and Biochemistry of Synaptic Transmission: Classical Transmitters - Ariel Y. Deutch and Robert H. Roth 8. Nonclassic Signaling in the Brain - Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts 9. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More - Juan C. Sáez and Bruce Nicholson 10. Neurotransmitter Receptors - M. Neal Waxham 11. Molecular Properties of Ion Channels - Jason Tien, Yuh Nung Jan and Lily Yeh Jan

SECTION II. PHYSIOLOGY OF ION CHANNELS, EXCITABLE MEMBRANES AND SYNAPTIC TRANSMISSION 12. Membrane Potential and Action Potential - David A. McCormick 13. Biophysics of Voltage-Gated Ion Channels - Diane Lipscombe 14. Dynamical Properties of Excitable Membranes - Douglas A. Baxter and John H. Byrne 15. Release of Neurotransmitters - Robert S. Zucker, Dimitri M. Kullmann and Pascal S. Kaeser 16. Postsynaptic Potentials and Synaptic Integration - John H. Byrne 17. Cable Properties and Information Processing in Dendrites - Michael Beierlein

SECTION III. INTEGRATION 18. Synaptic Plasticity - Ruth Heidelberger, Harel Shouval, Robert S. Zucker and John H. Byrne 19. Information Processing in Neural Networks - James J. Knierim 20. Learning and Memory: Basic Mechanisms - John H. Byrne, Kevin S. LeBar, Joseph LeDoux, Glenn E. Schafe and Richard F. Thompson 21. Molecular Mechanisms of Neurological Disease - Monica Gireud, Natalie Sirisaengtaksin and Andrew J. Bean

Editorial Reviews

"John H. Byrne and James L. Roberts, who treated us to a superb textbook in their first edition of From Molecules to Networks, have now returned with another outstanding effort in the second edition. They have not only updated their comprehensive book but added to it important new sections on the molecular biology of neurological disorders and on the logic of informational processing by neural networks, the two key themes emerging in modern neuroscience. This book will be welcomed by students and experienced scientists alike as a coherent and valuable resource on cellular and molecular neuroscience.? -Eric R. Kandel, Howard Hughes Medical Institute; Columbia University College of Physicians and Surgeons, New York, USA "The world of neuroscience is extraordinarily broad and complex, ranging from molecular biology through neurotransmission to neuronal networks and brain disease. How can one convey to the student and professional coherently the 'big picture' without sacrificing critical detail? In the second edition of their now classic volume, John Byrne and James Roberts accomplish this task with rigor, elegance and, remarkable lucidity.The volume will be indispensable both for student and advanced researcher .? -Solomon H Snyder, Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry, Johns Hopkins University, Baltimore, USA "The development of systems biology across all of biological sciences has underlined the need for a neuroscience book whose goal is to span the range from molecular mechanisms to the neural substrate of behavior. The first edition of Byrne and Roberts was ahead of its time in doing what has now become the fashion. That was a wonderful book, and the second edition is even better. A 'must have'.? -Charles F. Stevens, Professor and Vincent J. Coates Chair in Molecular Neurobiology, The Salk Institute for Biological Studies, San Diego, USA "This second edition brings up to date a superb neuroscience book, further enhancing its unique original strength-elegance thoroughness, and clarity, contextually presented.? -Rodolfo Llinas, Thomas and Susanne Murphy Professor of Neuroscience and Chairman, New York University Langone Medical Center, New York, USA